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Jan 22 2021 09:44pm
https://torontosun.com/news/world/who-advisor-covid-19-pandemic-started-via-a-lab-leak

WHO advisor: COVID-19 pandemic started via a lab leak :rolleyes:

This post was edited by GarryGarry on Jan 22 2021 09:44pm
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Jan 22 2021 09:45pm
Quote (Thor123422 @ Jan 22 2021 02:05pm)
It's such a headache having to explain the importance of false negatives and false positives to people over and over.


That's something that needs to be taught in high school. Understanding probability, basic statistics, etc. is required in almost EVERY field.
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Jan 22 2021 09:49pm
Quote (Bazi @ Jan 22 2021 05:01pm)
That is so sad/bad because false negative rate on the tests is not negligible


PCR was never designed to be a diagnostic test.
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Jan 22 2021 09:58pm
Quote (EndlessSky @ Jan 22 2021 09:49pm)
PCR was never designed to be a diagnostic test.


Thats a really stupid thing to say. Anything can be a diagnostic test. PCR is actually well suited to being a diagnostic test since primers are very specific and its easily scalable.
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Jan 22 2021 10:07pm
Quote (Thor123422 @ Jan 22 2021 10:58pm)
Thats a really stupid thing to say. Anything can be a diagnostic test. PCR is actually well suited to being a diagnostic test since primers are very specific and its easily scalable.


How many threshold cycles?
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Jan 22 2021 10:10pm
Quote (EndlessSky @ Jan 22 2021 10:07pm)
How many threshold cycles?


Needs to be optimized depending on the application.

You like to just repeat what you've heard without actually taking the time to understand it and it makes you look like a moron. This is just the most recent. You do it like every week.

This post was edited by Thor123422 on Jan 22 2021 10:11pm
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Jan 22 2021 10:14pm
Quote (Thor123422 @ Jan 22 2021 11:10pm)
Needs to be optimized depending on the application.


Correct assessment.

The mathematics is that the optimal is about 25.

Too low threshold cycles and the false negatives are too high.

Too many and the false positives are too high.

Either way the test has poor accuracy even at the optimal point.

This post was edited by EndlessSky on Jan 22 2021 10:16pm
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Jan 22 2021 10:15pm
Quote (GarryGarry @ 22 Jan 2021 22:44)
https://torontosun.com/news/world/who-advisor-covid-19-pandemic-started-via-a-lab-leak

WHO advisor: COVID-19 pandemic started via a lab leak :rolleyes:

this cant be true, the world’s politicians last year other than Trump said this was “fake news and hysterical xenophobia”
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Jan 22 2021 10:18pm
Quote (EndlessSky @ Jan 22 2021 10:14pm)
Correct assessment.

The mathematics is that the optimal is about 25.

Too low threshold cycles and the false negatives are too high.

Too many and the false positives are too high.

Either way the test has poor accuracy even at the optimal point.


Doctors are specifically trained to take this into account. Theres specific training on evaluating diagnoses in conjunction with false negatives and positives.

Really we should probably be using less sensitive tests that are faster and wont detect non contagious low viral loads. But we have what we have and its better than nothing
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Jan 22 2021 10:20pm
Quote (excellence @ Jan 22 2021 10:15pm)
this cant be true, the world’s politicians last year other than Trump said this was “fake news and hysterical xenophobia”


If he really thinks that he had better have some peer reviewed literature to back it up.

So far there has been no evidence if human interference in the viral genome, and we know what to look for so thats a pretty good indicator.
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