Horazon's Focus is an essential charm for any melee characters. For me however, +24 stats is the only thing being of use.
Going back to Act2's Tal Rasha's Tomb.
Killing the guy guarding Duriel's Lair, we get the portal that allows us to face Tal Rasha himself.
Thing is, you're turned into Baal while fighting him
Tal Rasha is surrounded by his allies (who's bodies you can see on the floor), and he takes no damage unless all of them are dead.
Easy level though