I'm a Sr. Sys. Admin at a fortune 500 and we use a combination of Windows built in AV along with INTUNE for monitoring. However, an AV will only do you as good as you let it. What I mean is, if you are the type who constantly turns off your firewall/AV/Protection to gain a few extra frames, or because it pops up too often or whatever, it will obviously be less effective. The key is to find a happy medium with configuration to not bother you incessantly while also offering you a comprehensive protection. No AV is perfect, just as no security system is perfect. The reason we use INTUNE/Windows Defender, is the speed at which it is updated and its simplicity with configuration.
Just my .02