As far as i know, no it shouldn't ruin it. Either way.. I don't recommend running andariel. She drops worse drops than mephisto, diablo and baal. I recommend running only diablo and baal, or only diablo. He is the easiest to get to and drops the best drops.
You can test andy drops by noticing if these items drop:
https://forums.d2jsp.org/topic.php?t=71142281"Quest drops ensure you won't get any white items, arrows/bolts, potions, or any other "trash" from the drop."
I don't think gems is included in this list, because andariel usually always drop a gem of some kind.