my favorite part about all the rune calculations is we are leaving out the tens of thousands of gems you will also need.
Gems are trivial
The caveat to this is gems bellow flawless drop at a lower rate in hello difficulty, increasing in rarity the lower the quality - so chips will actually hold more value than runes, eventually.
the main point to take away from this is that
everyone now has a dedicated stash tab for their mats that stack up to 99, and once the respective slot is fully saturated you'll be forced to up to the next unit, and so on, until you're eventually just making Zods from Els. The question isn't if, but when. It is an inevitability.
You dont even need to saturate each slow, you can just start when you have enough runes to up to the next and just manage your stash that way, the point is that you now have an extremely efficient way to do this.