pathogens are at an all time high because of that seed of cain sunlight blocking practice:
https://ctmucommunity.org/wiki/Parasitic_Divergencethe soul stone of diablo at the pineal gland, aka calcifying it and glassing it in order to corrupt it.
the moment i saw the diablo animations i knew the demon possessed seeds of cain jad been screwing with humanitys god gateway for centuries.
The world stone has long been corrupted. There is no going back