Quote (TeenyUncle8 @ May 19 2025 08:21am)

Prostate cancer is just nasty. I had a coworker who discovered his late like this. It had metastasized. It’s really not that uncommon with prostate cancer.

I know everyone wants to slap on their tinfoil hat, but it’s just a nasty cancer and a shitty situation. It’s really not deeper than that.

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how fast does a Gleason score 8 or above prostate cancer metastasize?

Prostate cancer with a Gleason score of 8 or above is classified as high-grade, indicating aggressive cancer cells that are more likely to grow and spread quickly compared to lower-grade cancers. The rate of metastasis (spread to other parts of the body, such as lymph nodes, bones, or organs) varies depending on several factors, including the specific Gleason score (8, 9, or 10), the primary and secondary Gleason patterns, PSA levels, tumor stage, and whether treatment is initiated. Below is a detailed overview based on available information:
General Timeline for Metastasis
Gleason Score 8 (Grade Group 4): This includes patterns like 4+4, 3+5, or 5+3. These cancers are aggressive but somewhat less so than Gleason 9 or 10. Without treatment, metastasis may occur within 1–3 years in many cases, particularly to lymph nodes or bones, though this can vary widely. Studies suggest that Gleason 8 cancers with a pattern 5 component (e.g., 3+5 or 5+3) may have a worse prognosis than 4+4 cancers, with a higher risk of metastasis.

Gleason Score 9–10 (Grade Group 5): These are the most aggressive, including patterns like 4+5, 5+4, or 5+5. Untreated, these cancers can metastasize more rapidly, potentially within 12–24 months or even faster in some cases, especially with patterns like 5+4 or 5+5, which show poorer outcomes. For example, a 2020 study found that at 10 years, the risk of prostate cancer death was 45% for Gleason 4+5, 56% for 5+4, and 66% for 5+5, indicating increasing aggressiveness with higher pattern 5 proportions.

Population-Based Data: A SEER database analysis (2006–2008) of metastatic prostate cancer (mPCa) patients with Gleason scores 6–10 showed 4-year prostate cancer-specific survival (PCSS) rates of 44% for Gleason 8, 33% for Gleason 9, and 21% for Gleason 10, reflecting higher metastatic potential with increasing scores. This suggests that Gleason 8–10 cancers often present with or progress to metastasis within a few years if untreated.

Quote (ofthevoid @ May 19 2025 06:30am)

Discovery =/= how fast it actually metastasizes. It's pretty common to discover these at advanced stages, as with other cancers.

What's unbelievable is that this was missed when Biden at 81 would be seeing a physician very frequent given his state and given he's literally POTUS.

Here, hope this helps

Quote (TeenyUncle8 @ May 19 2025 08:46am)

You guys are ridiculous. You really think that this just manifested itself because of the hur tapes? That was a big story a year ago when Biden was president and running for another term. Nobody cares at this point. It just confirms what everyone knew, that he was an elderly man a year ago, shouldn’t haven been running for reelection, and is no longer president nor running for reelection. It’s a story that would have blown over in a day or two and people would move on to things that actually impact them.

Seems like Biden derangement syndrome is every bit as unhinged as TDS which people seem to love to throw out there.

Quote (ofthevoid @ 19 May 2025 15:01)

"The people that lied about Biden's mental acuity in chorus calling him Sharp as a Tack, surely wouldn't lie about this"

Child like naivety

Quote (ofthevoid @ May 19 2025 07:01am)

"The people that lied about Biden's mental acuity in chorus calling him Sharp as a Tack, surely wouldn't lie about this"

Child like naivety

Quote (Black XistenZ @ May 19 2025 09:11am)

That's fair and all, but like I said: even if they did cover it up while he was president, why didn't they make it public and start treatment right after Biden had left office? Why wait 4 more months and give the cancer more time to grow and metastasize?

Quote (TeenyUncle8 @ May 19 2025 06:21am)

Not everything is some deep dark conspiracy perpetrated by the left. Sometimes elderly folks just… you know… get sick.

Quote (TeenyUncle8 @ May 19 2025 08:21am)

Not everything is some deep dark conspiracy perpetrated by the left. Sometimes elderly folks just… you know… get sick.

Quote (Goomshill @ May 19 2025 09:05am)

Even the fastest growing prostate cancers would be detectable on a thorough exam 6-12 months before it could spread. Its not like a lymphoma or glioblastoma that can spread rapidly out of nowhere. The rare form of small cell prostate cancer is fast enough to skirt inbetween regular exams for normal patients, but there's an expectation that the sitting president of the united states of america would be getting care above and beyond that. His PSA levels should have been high enough to pick it up before he left office just from a blood test. Again it has to be stressed, prostate cancer is slow. The slowest. 5 year survival rate of 99%+. Its the most screened for and treatable, usually the easiest to catch localized and offer surgery or radiation. The whole reason prostate exams are so many years between is because there is such a huge window to treat it even if its undetected for years, prostate cells replicate at a snails pace

It takes a confluence of unlikely factors- a rare form of disease, a window between prostate exams, the white house physician taking a lax approach. All coinciding with revelations about Biden hiding his other chronic conditon but 'trust me bro' on this one.

It happens, its possible its what it looks like at face value and unlucky. Dilbert writer Scott Adams revealed on his stream today he's got the same type and had it longer and expects to be logging off his account this summer. But he wasn't the US president. This is precisely the kind of thing that could be tested for with overly zealous care