Is it possible to defeat negative feedback in terms of neurotransmitter activity?

Example: take amphetamines, they cause increased dopamine to be released into the synaptic cleft.

What are the ways of negative feedback?

1.Increase MAO-B the enzyme digesting dopamine in the synapse.
2. Increase the number of dopamine reuptake transporters, so more dopamine is transported out of the synapse back into the presynaptic neurone.
3. Decrease the production of dopamine in the cell body, soma.
4. Decrease the number of dopamine receptors at the postsynaptic neurone

(if there is any other way lmk)

Now we can give L-DOPA which gets converted into dopamine.
We can herewith defeat Part 3 as we can have dopamine without its production in that case.
Part 1 can be defeated by giving seligiline an mao-b inhibitor
Part 2 can be defeated by dopamine reuptake inhibitors
Through certain hormones, that regulate up and down regulation of receptors we might defeat part 4.


Conclusion: We have defeated the negative feedback loop and are no more in need of dopamine producing drugs, (faith establisher) such as christianity and other religions for a happy life.

My question: what factors are likely to occur that contradict my conclusion and is there a solution 4 it?

This post was edited by MyAccountIsOsterHues on Oct 1 2010 07:53pm

Mindfuck'd.

Great now I have a headache.

enjoy

The biology behind it seems correct, but your conclusion is lol.

y its lol but true.

Cuz you reduce religion to a feeling.

Without feeling what is religion?

Does religion value feeling over rational thought? Seems to me basic concept preached by major religions is fight against your feelings/temptations. The consequence of such a thing is at first a negative emotion, but if the person thinks at a higher level, then this negative emotion becomes a positive one. So I wouldn't say physical happy feelings is the goal of a religious person, it's more of a psychological consequence imo. Feelings is the most important thing to a disbeliever, since he thinks there's no life except this one, so he strives for immediate temporary pleasure ("enjoy life while it lasts"), while the believer in theory sees this life as a prison and strives for the afterlife. Anyways, we cannot ignore that both individuals ultimately strive for happiness.

My point is:

OP is reducing the complexity of the human being into a couple of molecules, it certainly isn't the case. Modern science can't always answer questions related to human behavior, especially those that concern irrational behavior. Yes we are discovering more and more, but that only shows us that man is complex, perhaps the most complex of living beings on the planet.

BTW, if molecules/drugs could do the job of keeping us happy then drug addicts would be at the top of chart in terms of happiness and self-fulfillment. They obviously are not.

like putting on a vest with explosives then stuff metal ball bearings and nuts/bolts next to the explosives then walking into a crowed market and indiscriminately killing? all the while killing you self for the sake of Paradise which includes 70 virgins or something?

oh

Praise Allah

This post was edited by five33 on Oct 11 2010 05:26pm