I know you said google didn't work but search negitive effects of anti depressants. You have to have a broader search range.

It would be difficult for me to explain it. Massive intakes, it wouldn't matter what they do, its bad. Immune system problems I'm not to sure but it could very well do that,

Which anti-depressants were you on?

Massive intake of an SSRI(Zoloft, Celexa, Prozac, Paxil+more) would cause a serotonin storm, which is pretty dangerous. Do you mean just large, regular doses? If you were on an SSRI, that wouldn't touch your immune system and I've never heard of a research paper discussing an adverse side effect of an SSRI to be immune system damage.

The other major class of antidepressants is MAOI's and I've never heard of them messing with the immune system either. In fact, it doesn't really make sense that an antidepressant would effect the immune system. The act on the synapses to increase or decrease the amounts of neurotransmitter, specifically serotonin. The immune system is regulated in a system different than the serotonin pathways in the brain. So it may not be impossible, but its a very unlikely sideeffect

Not to mention that depression itself can seem as a problem with your immune system.

"Most of the toxic effects of TCAs are caused by four major pharmacological effects. TCAs have anticholinergic effects, cause excessive blockade of norepinephrine reuptake at the postganglionic synapse, direct alpha adrenergic blockade, and importantly they block sodium membrane channels with slowing of membrane depolarization, thus having quinidine like effects on the myocardium.[6]"

This indicates that using too much of this particular drug can slow your heart rate and eventually cause toxicity of heart muscle. In any case, whether it influences your IS is probably a very minor mechanism due to the fact that the drug does not cause one of the following:

1. Anemia
2. Immuno-deficiency symptoms
3. Lysis (destruction) of blood cells
4. Leuko-encephalitis symptoms

Remember that blood is a very crucial component of your Immune System, if none of the actual bodies of blood or lymph production are affected, then your immune system is probably fine. Some drugs that do affect immune system: Heroin, Crack, and Methamphetamine.

If tricyclics killed your immune system, you'd be the first.