Biology in theory can be reduced down to chemistry, which can be reduced down to physics, but things grow tremendously complex and its not worth it.
However, I think that mathematical models cannot apply to biological systems that easily. For instance, mathematical models cannot fully represent true biological phenomena because they don't account for the spatial factor. Additionally, they only assume that all chemicals can react with each other without accounting for inhibitory events, or other kind of interactions such as adhesive properties, hydrophobic interactions, etc, etc....Moreover, they can be manipulated until they work.
Some scientists (even legit ones) introduced some kind of these supposed models into computers, played with complexity and supposedly got some incredible hidden patterns that miraculously emerged, in other words, nothing less than bacteria, flowers, animals, etc...
Now i think this is an example how wrong initial assumptions, when used in wrong ways, can lead us to monstruously misleading conclusions.
If your approach in order to answer how from complex primordial chemistry we got to today’s life is this, then it is life answering to the question how from 1, 2, 5, 8 you got 5689 and you claim: Eureka!!! Its 1+2=15*5=3000*8=5689
On the contrary, I think that in a complex chemical system, due to all the kinds of interactions which are unpredictable, the most sustainable combinations of interactions (or else the resulting mixture) will be slowly selected in a step-by-step fashion, brick by brick, until we get the final mixture that will be super sustainable because it was sculped and shaped by eons of struggles and competitions.
In other words, i think that biology should be studied by biologists, and mathematics cannot make real-life cntributions...