It really depends on the person. I know that if you don't have sleep for more than 72 hours you will experience pronounced delirium and difficulty producing coherent thoughts.

Depravation of sleep will lead to a lack of thought, you will experience paranoia, some craziness ofc, and well other things such as slower reaction times...etc.

Where did you learn neuroscience...

Parkinson's is from a reduction of dopamine in the substantia nigra leading to difficulties controlling movement, not an increase... L-Dopa is taken because it can easily be turned into dopamine in the brain and then used to help control muscle movements...

And they still arn't sure if dopamine is a major leading factor in schitzophrenia it is just a theory, it could also be glutamate, gaba, or serotonin.

L-DOPA is the L-DOPAMINE Isomer. It decreases D-Dopamine levels, which is what causes Parkinson's disease like symptoms at higher levels.

[QUOTE=Jazz_Thing,Wed, Aug 5 2009, 10:50am]L-DOPA is the L-DOPAMINE Isomer. It decreases D-Dopamine levels, which is what causes Parkinson's disease like symptoms at higher levels.[/QU

L-DOPA is converted into DOPAMINE in the brain... and is the gold standard right now for treating parkinson's disease...
L-DOPA is decarboxylated in the brain by an enzyme that turns it into dopamine.

http://neurology.health-cares.net/parkinsons-disease-l-dopa.php


Just one website that talks about it... I'm sure with more time you can find stuff in scientific journals but i'm at work so i can't...

Low level's of dopamine is the cause of parkinson's disease, for example some of the newest literature involves the transplanting of dopaminergic neurons into the substantia nigra and adding neurotrophic factors so that the dopaminergic neurons can reinervate the putamen and the caudate thus increasing dopamine levels and reversing effects of parkinson's disease. Why would they use a medication that lowers dopamine levels to treat a disease caused by low levels... They wouldn't... L-DOPA raises the amount of dopamine in the brain... Do some research

This post was edited by pms5025 on Aug 5 2009 01:01pm

oops

This post was edited by pms5025 on Aug 5 2009 01:01pm

[QUOTE=pms5025,Wed, Aug 5 2009, 06:56pm][QUOTE=Jazz_Thing,Wed, Aug 5 2009, 10:50am]L-DOPA is the L-DOPAMINE Isomer. It decreases D-Dopamine levels, which is what causes Parkinson's disease like symptoms at higher levels.[/QU

L-DOPA is converted into DOPAMINE in the brain... and is the gold standard right now for treating parkinson's disease...

http://neurology.health-cares.net/parkinsons-disease-l-dopa.php

Just one website that talks about it... I'm sure with more time you can find stuff in scientific journals but i'm at work so i can't...

Low level's of dopamine is the cause of parkinson's disease, for example some of the newest literature involves the transplanting of dopaminergic neurons into the substantia nigra and adding neurotrophic factors... Why would they use a medication that lowers dopamine levels to treat a disease caused by low levels... They wouldn't... L-DOPA raises the amount of dopamine in the brain... Do some research[/QUOTE]

Why are you trying to prove me wrong? If you take more L-Dopamine (L-Dopa) your brain Dopamine levels will increase! Your D-Dopamine levels will decrease, its more complicated than just decreasing its actually a process of RE-UPTAKING! Where did I learn neuroscience? I learned in neurophysiology/chemistry classes as well as a few psychology classes. (University level)

Let me ask you do you know the difference between L-Dopamine and D-Dopamine chemically?Since you seem to be an expert in somehow agreeing with me.

They would use L-Dopa to increase your brain Dopamine levels, but only of the L-Dopamine chemical, not the D-Dopamine or simply Dopamine chemical.
What is the difference between L-Dopamine and Dopamine chemically?

Actually my first quote says Low dopamine levels causes symptoms similar to parkinsons. I'll paste it here:

This post was edited by Jazz_Thing on Aug 5 2009 01:10pm

[QUOTE=Jazz_Thing,Wed, Aug 5 2009, 02:06pm][QUOTE=pms5025,Wed, Aug 5 2009, 06:56pm][QUOTE=Jazz_Thing,Wed, Aug 5 2009, 10:50am]L-DOPA is the L-DOPAMINE Isomer. It decreases D-Dopamine levels, which is what causes Parkinson's disease like symptoms at higher levels.[/QU

L-DOPA is converted into DOPAMINE in the brain... and is the gold standard right now for treating parkinson's disease...

http://neurology.health-cares.net/parkinsons-disease-l-dopa.php

Just one website that talks about it... I'm sure with more time you can find stuff in scientific journals but i'm at work so i can't...

Low level's of dopamine is the cause of parkinson's disease, for example some of the newest literature involves the transplanting of dopaminergic neurons into the substantia nigra and adding neurotrophic factors... Why would they use a medication that lowers dopamine levels to treat a disease caused by low levels... They wouldn't... L-DOPA raises the amount of dopamine in the brain... Do some research[/QUOTE]

Why are you trying to prove me wrong? If you take more L-Dopamine (L-Dopa) your brain Dopamine levels will increase! Your D-Dopamine levels will decrease! Where did I learn neuroscience? I learned in neurophysiology/chemistry classes as well as a few psychology classes.

Let me ask you do you know the difference between L-Dopamine and D-Dopamine chemically? Since you seem to be an expert in somehow agreeing with me.

They would use L-Dopa to increase your brain Dopamine levels, but only of the L-Dopamine chemical, not the D-Dopamine or simply Dopamine chemical.

What is the difference between L-Dopamine and Dopamine chemically?[/QUOTE]

L-DOPA is carboxylated.. while the NT Dopamine isn't carboxylated... In the brain the Carboxyl Group is removed by aromatic-L-amino-acid. This amino acid decarboxylates the L-DOPA turning exactly into dopamine the same stuff you get out of the substantia nigra... Thus increasing dopamine in your brain to alleviate symptoms of Parkinson's Disease.

In my first quote I said that low dopamine causes parkinsons like symptoms, yet you keep badgering this thread. In any case, yes you're right and the Carboxyl group causes the formation of the L-Dopamine molecule, which is actually a carboxylated isomer of Dopamine itself.

L-Dopa causes immediate reuptake with increases in brain dopamine levels, which as we agreed...from the first quote alleviates parkinson's like symptoms. High dopamine levels causes varied but generally schizophrenic and paranoid symptoms.



L-Dopa is a multipurpose drug it actually reuptakes and normalizes Dopamine levels. I should have said that from the beginning, my mistake.

This post was edited by Jazz_Thing on Aug 5 2009 01:18pm

I believe you say here that L-DOPA decreases Dopamine levels and that at high levels you have parkinson's like symptoms and schizophrenic symptoms

"During High Dopamine levels, a drug known as L-Dopa which is basically an isomer(similar molecule different structure) of the Dopamine neurotransmitter which DECREASES your brain Dopamine levels. This reduces the effect of Parkinson's-like symptoms and the schizophrenic symptoms talked about above, (Jazz)."

I'm arguing that it doesn't decrease dopamine levels, that it raises dopamine levels, and it's not the decrease that reduces the effect of parkinson's-like symptoms, it's the increase in dopamine that does... So i'm not agreeing with you

And i keep spamming this thread cause i like the convo we are having

This post was edited by pms5025 on Aug 5 2009 01:19pm