how much is needed ? that's a hard question, it now more depends on luck

the thing is that for example, if you have 15% ls. Each hit, you get a chance to hit 1% ls or 2% ls or 3% ls....or 15% ls
so ls is much less effective than before

about your stuff, I have no idea :/
I used to no regen from lvl 55-71 with a very good weapon and 20% ls but I can't anymore ^^
so i'd say, you still need life steal but with a much better def

hope that helps you