I saw this post awhile ago... chose not to respond because people think I am nuts.
Personally, I don't rely on Regen gear in my inventory space, I use EES gear so that I can get more Shrine items stored on character, I have a certain method though, I will trash some crap items to make space for better shrine items, and I will say that using Mythical (+5) Tier III to Tier VIII items to keep you going in the late 60s to 75s ... sell off the Arcanes +, and if you do run out, just pick up the crap and shrine them off.
Test it out for yourself ... Mind you I do use an armor while exploring with +8 Life Regen, however, I hardly regen unless I come across EP waves regularly (wish this happened every run,
)
Oh, btw, always put your 3 EES items in your first 3 slots, this way, they should NOT be re-organized by the game mechanics.