I think it depends if you are using ignore pain with the iron hide rune an pride of Cassius as your belt if that's your combo with a bit of CDR from other items it may be enough to perma ignore pain. I'm assuming your using zodiac in cube or equipped so that helps with perma wrath along with boon of bul kathos. With this set up would
I only consider IAS even more so on HC
So imo CDR > ias or area damage