What are the implications of fitness, particularly body building, and caffeine use?

caffeine potentiates neuromuscular function and stimulates some metabolism by way of ep/norep signalling, glut4 translocation and ffa lipolysis slightly elevated

increased ability to lift buildings
increased adrenal fatigue

Thanks, that's good information.

If bulking, would one need to increase caloric intake by any amount to augment the influence on metabolism?

ehh prolly not. may cause some respiratory uncoupling but were probably talking individual calories here <-- thats my guess based on knowledge i have

This post was edited by cloudkicker on Feb 27 2015 09:01am

Gold mine:

http://www.nutritionandmetabolism.com/content/10/1/71

caffeine on athletic performance

This is pretty much all true:



though there's not much epi/norepi signaling by caffeine unless taken in gross excess. Coffee has more via the beta carbolines (MAOIs) helping facilitate a longer action there

in general it really is important to differentiate between coffee and caffeine only as well. IIRC coffee also has chlorogenic acid & caffeic acid, that stimulates AMPK, which explains a lot of the effects on GLUT4 expression (apart from Ca2+ influx through ryanodine receptors). Luckily for the OP, it's the alpha 2 isoform that's upregulated so the canonical mTOR antagonism through TSC1/2 doesn't occur.

coffee's just a beastly beverage, i think there are implications in reducing oxidative stress, preventing neurological degeneration, systemic inflammation and all sorts of shit. pretty interesting thoughts

ive gotten pretty interested in reading about new cancer therapies lately, there are some really innovative sounding approaches posted in r/science

Try mate. That's the shit yo.

Forreal though
I've read 2 studies in the past year or so that indicated coffee reduced the # spontaneous DNA strand breaks by quite a significant amount. That's a pretty crazy discovery on top of everything else lol

But despite all this... I hear it pontificated probably weekly, from someone at school or work, that coffee/caffeine is awful for you and will cause heart problems and premature death lolol

And like what? I haven't kept up with any cancer research lately, not as interesting to me as other things I guess haha. The last thing I remember reading, which was like a full year ago (or more) was about the use of TRAIL ligated to leukocytes to cause mass apoptosis in metastasized cancers

Can you explain what you just say in your last two posts but break it down to like full retard level?