Quote (Balla @ Feb 26 2015 12:31am)
mixture of increased mechanical tension (think mechanotransduction biochemically) and metabolic stress (biochemically, think occlusion, cell swelling, lactate and H+ ion accretion, etc.. also secondarily increases muscular damage aka microtears, augmenting the myokine response).
It basically elevates everything associated with hypertrophy.
Volume is the most important constituent of hyp. Intensity does need a relative minimum and for all intents and purposes let's say above 60% 1rm is solid. Frequency you're probably better off with being higher, 2-3x/week as doing 30 sets for chest in 1 workout vs doing it in 2 workouts over the course of an entire week sustains elevations in protein synthesis & myogenic gene expression longer.
Think overall there's more of a reason for muscular adaptation to occur and the muscle experiences greatest fatigue.
I do 30 sets of chest in a workout twice a week O.O sometimes 35 or 40, if you include flies