would a statin be helpful for offsetting certain side effects of other "things" that may affect bone strength?

It's a HMG-CoA Reductase inhibitor a rate limiting enzyme in cholesterol synthesis, it has no action on bones.

inb4 - myopathy preventing lifting making you give up lifting and having weaker bones as a result because you wanted to take some random class of drugs which have a purpose you don't even understand.

Also: Inb4 - you look up the class of bisphosphonates and try to get a script from your doc at like 20...

what is affecting bone strength.

if it is aas, it is going to be your tendons and joints that are just dry and hurting

He should take quinolones instead.

doesnt aromasin have a reputation for hurting bone density?

im not taking it, but just curious and learning for the sake of knowledge

at a higher dose over extended periods of time.. however you should use arimidex or letrozole anyway

Actually, -statins cause myopathy (muscle pains, aches, and weakness in a few % of the cases, but is precipitated by certain factors).

Yup
it may also impede muscle growth via a negative modulation on satellite cells
and a negative effect on mitochondrial biogenesis
Estrogen is there for a reason, even in males, and plays integral roles, despite many lifters fear of it

Now, on to your original query about bones & statins..

Statins actually promote bone growth. When I attended that national research conference (and won ) a couple of months ago, I heard an enthralling talk on Cholesterol, statins, and HMG-CoA reductase from a top researcher in the field that's been working on this for yearsss. I learned a ton about all nuances within the molecular crosstalk, about the degradation of HMG and the factors involved like insig-1 binding to either SCAP or the HMG reductase itself, Ubiad1, etc.. anyway, onto your point.

One interesting, albeit highly complex, topic he touched on were the various DOWNSTREAM pathways of HMG-CoA reductase (which is very upstream, the rate-limiting step), which includes the various signaling modulators like mevalonate (and that pathway in general) and the influence of prenylation, for instance. So yeah, through inhibiting HMG-CoA reductase, and thus those downstream effectors I touched on (though I'm not that well versed on the topic, it's complex as fuck and I know the bare minimum from a single 45 minute talk lol), statins may promote some bone growth.

Oh and statin influence on skeletal muscle is as the others said - it MAY cause myopathies though that's somewhat rare. Overall, they do generally reduce strength & muscle gain, though even that's not completely lucid, but somewhat likely. Generally not good here. Lol.

I'm gonna have to google 50% of what you wrote to come up with a response to that hahaha

This post was edited by ViviLOL on Jan 11 2015 09:56pm