"Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle"

http://diabetes.diabetesjournals.org/content/52/3/657.long

Interesting tid bit from the results section: "An important feature of the data from this study, however, was that the absolute change in transcription in response to fasting and refeeding varied considerably among subjects."

Adds even more corroboration to the fact that idiosyncrasies govern most bodily responses.. this holds true only for the few specific genes they tested, but still adds weight to that fact.

The changes they found essentially lend more credence to the increased reliance on FFAs vs glucose in response to fasting.

What's most striking & important to me out of all these findings, however, is the robust upregulation of UCP3 expression. This also adds credence to possible longevity increases via intermittent fasting protocols (mimicking caloric restriction).. this is just another mechanism by which it may occur. UCP3 limits free radical production and is overall protective, as well as boosts metabolic rate and is involved in lipid metabolism.

http://www.cell.com/cell-reports/pdfExtended/S2211-1247(14)00669-X

"AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner"

More info on AMPK.

First study would give even MORE credibility to implementing IF in a bb pre-contest diet, yeah?

Lol, this should just be renamed Shane's thread

Glycogen refills -not refeeds- during prolonged dieting. What to look out for and how to plan it.

https://www.facebook.com/permalink.php?story_fbid=296174760589011&id=175556779317477

This post was edited by Lightman on Oct 5 2014 04:38pm

Nice.



Haha nah. I just keep it updated with studies and such. Others are always more than welcome to comment on things and spark discussion too! Would be great tbh.



Eh doubtful.
I'm actually not sure, but I think on a prolonged severe deficit like pre-contest prep, you may be better off with a higher meal frequency and not fasting for 16-20 hours. I know under normal conditions that won't really impede muscle growth or make you catabolic under a normal cut.. but when you start becoming very depleted and low bf %, catabolism is pretty rampant, cortisol is extremely high, etc.. it seems prudent to increase meal frequency in hopes of keeping mTOR and anabolic pathways up as much as possible. Imo at least.
e: though that's more Liron's thing, so I may be off base there.. it just makes sense mechanistically.

This post was edited by Balla on Oct 7 2014 05:40pm

Trying to really delve into chronobiology.. specifically the food-entrained control over circadian signaling and effects on hormonal and metabolic modalities. A lot to go through and so far nothing too definitive, seems this area needs more exploring.
All in all, I'm trying to link fasting w/ circadian rhythmic changes and effects on metabolism and hormones. It's really not a question of should you or should you not fast.. you absolutely should. But what exact time period? And how long is optimal? It also seems that it's probably best to stick with a typical feeding pattern though.. so it may be highly individual + there may not be an optimal one, just depends on your own long term pattern.

In the lab today, going over some T-lymphocyte signal transduction for some classmates. All straight from memory

berkhan talks about it in enough depth. the exact fasting period to harmonically tie with circ rhythms is highly dependent on systemic individuality, inherent genetic variance, daily go-about 's, sleep patterns and more, it'll need regression math to work out and only to appease a certain populous byproduct much like a BMI chart.

As expected too, unfortunately.
Thanks though
still an interesting field however

hey, a BMI chart is still a decent indicator to non lifters, as much as reformed BMI chart for lifters can be- if anyone cared enough to meta-analyze such a global chart for such a small population sample.
if you really want to you can build a regression to find out the proximate age/sex/height/other-parameters indicator for fasting. it'll take time, effort and funding though.