This is a fukn goldmine

"Metabolism as a key to histone deacetylase inhibition"

http://www.murdock-trust.org/resources/partners/files/Metabolism%20as%20a%20key%20to%20histone%20deacetylase%20inhibition.pdf

In related news, circumin is a histone acetyltransferase inhibitor.. which is why I'll never supplement with it. I doubt it's really too significant, but absolutely, histone acetyltransferase ACTIVATORS or histone deacetylase INHIBITORS augment memory and learning capabilites.

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Too many benefits and protective qualities against my grandfather's horrible genetics. Have only noticed an increase in memory and learning scores since taking consistently for over a year.

when he said primary intake i assumed like 250g CHO per day out of a 300ish gram daily carb intake consisted of skittles. primary meaning you basically eat skittles and then cover protein and fat needs.

Yep exactly as I said on Alan's post. I basically mean skittles to fill the left over carbohydrates after or as you take in all the fiber, proteins, fats, micros. And I think with adequate exercise, that can certainly take away from whatever negative effects

New link

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254183/



You're correct though, there are definitely a multitude of benefits and such w/ circumin use.

and that's interesting.. I suppose that implies the inhibition property isn't too robust then? Too bad it hasn't been specifically tested.. I say that because the basis behind memory, LTP, when CREB & CBP are doing their DNA binding to induce gene expression and sustain/maintain the LTP long-term (aka long term memory) they recruit histone acetyltransferase in an integral fashion.

rHehe, I'm blessed in the genetics department. On my dad's side, I can't think of a single closely-related family member that didn't live until at least 85-95. My great grandmother was 90, her sisten was 93, and another 4-5 relatives with them all lived until 90, 91, 88, so on. Crossing my finers I received them heavenly blessed longevity genes as well

Here's the blessed genetics from my mothers father:

Colon Cancer
Bald
Skin Cancer
Multiple heart attacks - Now a pacemaker
And now Parkinsons

Granted the man was a boat captain under immense stress and chain smoked/drank like no tomorrow. Then was the owner of a few pizza restaurants = more stress. Had six kids etc. Not taking my chances lol, I mainly use it to stave off colon/heart problems since I already have had trouble with IBS.

My great grandmother lived to 95 but dementia took her over.

Hopefully it doesn't inhibit memory formation too much, I'll let you know when I don't remember you

This post was edited by xGeArz on Aug 12 2014 11:50am

Can somebody explain soluble and insoluble fibers to me.

I'm debating on what to get. Soluble is like psyllium husk or wheat dextrin and insoluble is like cellulose.

But I'm not getting how cellulose mixes with water if it's insoluble. Explain?

What should I go with? I'm thinking cellulose so I can have those full poops and not feel like there's still more in me lol.

Also read that fiber helps control of insulin sensitivity, so that skittle diet could work

Soluble vs insoluble fibers have different properties in the gut. Soluble fibers form a sort of gel for the fecal matter, insoluble allows for clumping. Both are needed in some sort of balance for proper bowel function. Solubility refers to the ability of a substance to dissolve in water. If something is insoluble it will dissolve very little (sometimes in insignificant amounts such that we say not at all). Soluble compounds dissolve well in water

Something insoluble can be added to water and form a suspension, but a suspension isn't dissolved. Particles in suspension just disperse and float as they are. Dissolved particles form ions in solution, ie table salt (NaCl) breaks into its constituents Na+ and Cl-

This post was edited by cloudkicker on Aug 13 2014 12:02pm

So what would be more beneficial for more fulfilling bowel movements where you actually feel like u got everything lol.

How is a 2g insoluble/5g soluble ratio?
Or 5g unsol / 4g sol

This post was edited by tommyd323 on Aug 13 2014 12:16pm