Now, I'll put some more studies up - not that anyone is interested anyhow lol.

Two on oxaloacetate. It's an intermediate in many pathways.. yet it's quite interesting to note that simply administering it can induce such profound effects.

"Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway"

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988682/?report=classic

"Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis."

http://www.ncbi.nlm.nih.gov/pubmed/25027327

Very intruiging findings. I really don't know what to make of them at this point, my knowledge isn't enough yet.

Third study I've seen in very recent times on klotho now out:

"Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathway."

http://www.ncbi.nlm.nih.gov/pubmed/24911970

Good to see elucidation about more players involved in aging. Interesting to note some of the players that regulate klotho expression too.. Sirt1 plays a role, but not the cardinal one apparently.

It's already over 9000.

not high enough until I could break the scouters

"Ghrelin induces leptin resistance by activation of SOCS3 (suppressor of cytokine signaling 3) expression in male rats: Implications in satiety regulation"

http://press.endocrine.org/doi/pdf/10.1210/en.2013-2095

"Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21"

http://scibite.com/site/library/2014_8/1/0/25082895.html

fu ghrelin

"Glucose deprivation promotes activation of mTOR signaling pathway and protein synthesis in rat skeletal muscle cells"

http://scibite.com/site/library/2014_7/1/0/25074488.html



so true
ghrelin: ruiner of diets
powerful

This post was edited by Balla on Aug 2 2014 09:36pm

"Evidence of Contribution of iPLA2β-Mediated Events During Islet β-Cell Apoptosis Due to Proinflammatory Cytokines Suggests a Role for iPLA2β in T1D Development"

http://press.endocrine.org/doi/abs/10.1210/en.2013-2134

This is actually fukn exciting.
It's been oft hypothesized that the likely etiology of type 1 diabetes is certain enteroviruses (Coxsackie viruses) causing a sustained autoimmune disease, manifesting as TD1.. thus, knowing the cytokines involved and how they cause damage through various transduction pathways, is integral to possibly mitigating damage, maybe even reversing as time goes on? On that note: also general prevention.

"Duodenal CCK cells from male mice express multiple hormones including ghrelin"

http://press.endocrine.org/doi/abs/10.1210/en.2013-2165

Heh. How varied its secretions are. I wonder if, as epigenetics advances, we could selectively target silencing of certain genes, within certain cells. The implications could be enormous, and with my understanding of epigenetics, I don't see why we couldn't with time.