"New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis"
http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00142/full?utm_source=newsletter&utm_medium=email&utm_campaign=Neuroscience-w27-2014This article focuses on times of inflammation, when histamine levels would be increased.. however, I wonder about the normal, typical levels of histamine, and that function in the brain. It functions as a neurotransmitter, basally, and robustly mediates wakefulness. With those things in mind, I wonder about the use of anti-histamines potentially inhibiting/attenuating neural stem cell differentiation, and thus neurogenesis. I'll have to do more digging, but it seems like a possibility. That could have clinical implications, as many people do use anti-histamines frequently, esp to help them sleep. On top of the antihistamine inhibiting neurogenesis quandary, I would also like to see possible correlations.. such as, chronic anti-histamine users and links to depression, and other sorts of neurodegenerative diseases due to impaired inherent neurogenic function. Meh, this is all surmise anyhow.