"Drinking coffee burns hepatic fat by inducing lipophagy coupled with mitochondrial β-oxidation"

And for the science heads, it may bet worth to acknowledge that "[c]affeine may inhibit PI3K-AKT and, in turn, inhibit mTOR to trigger autophagy by activating the ULK1 complex, which includes ULK1, Atg13, FIP200, and Atg101. Autophagy selectively removes excess LDs to generate FFAs. Decreased mTOR induces TFEB nuclear translocation by decreasing TFEB phosphorylation. TFEB up-regulates expression of autophagy and lysosomal genes, as well as PGC-1α and PPARα, which burn FFAs by increasing mitochondria β-oxidation. Thus, caffeine protects against fatty liver by coordinately inducing lipophagy and mitochondrial β-oxidation."

Pretty interesting. Some elucidation into the hepato-protective effects of coffe. And just more mechanisms of it in general apart from the main ones



Then this... this was amazing, especially for the "clean" eating crowd

http://www.mdpi.com/2072-6643/6/3/1128
"The Effect of Normally Consumed Amounts of Sucrose or High Fructose Corn Syrup on Lipid Profiles, Body Composition and Related Parameters in Overweight/Obese Subjects"



Then last, an incredibly exciting find imo.. especially as someone into immunology and works in an immunologist's research lab lol;

"Scientists discover new, important immune function of TSH: Thyroid stimulating hormone acts as a T-cell developmental factor in mice and humans

As he researchers from the Netherlands point out in their latest paper they detected differential thyroid stimulating hormone receptor (TSH-R) expression during human T-cell development in the thymus.

"This expression pattern indicated a potential role for the TSH-R within the thymus, independent of its function in the thyroid gland."

In their latest experiments, they were now able to demonstrated that TSH-R expression is thymus-specific within the immune system. In fact, the THS molecules were able to bind and activate the TSH-R present on thymocytes. This lead to an activation of the calcium signaling and cAMP signaling pathways and did thus contribute to the development of T cells.

These findings are of potential clinical use to enhance, as they could be used to increase thymic output and thereby the functional T-cell repertoire in the periphery. They may also explain the thus far enigmatic thymic hyperplasia in Graves' disease, where TSH levels are constantly elevated."

Has anyone posted studies on smaller meals spread throughout the day vs one or more large meals?

In relation to what? There's plenty of studies floating around on meal frequency variations w/ caloric equality though

This post was edited by Balla on Mar 25 2014 11:41pm

If spacing calories throughout the day is better for metabolic rate than a single meal per day.

This post was edited by dark-soul on Mar 26 2014 12:24am

i approve this

http://journals.cambridge.org/action/displayFulltext?type=6&fid=9214735&jid=NRR&volumeId=-1&issueId=-1&aid=9214734&bodyId&membershipNumber&societyETOCSession&fulltextType=RA&fileId=S0954422414000055

"Physiological responses to food intake throughout the day"

any articles on rest time between sets?

in relation to hyp, strength, endurance, or?

Talk dirty to me.