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May 21 2019 12:02am
Quote (Neptunus @ May 21 2019 12:53am)
Which point are you referring to? I was talking about taking test for quality of life reasons in elderly men, which was associated with increased cardiovascular morbidity, and extrapolated it to young men. It may not be a valid extrapolation, but at least it hints towards significant physiological adverse effects in general.


Your claim assuming you’re talking trt, is controversial, and there’s not yet enough evidence to substantiate it.
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May 21 2019 03:37am
Quote (tommyd323 @ May 21 2019 08:02am)
Your claim assuming you’re talking trt, is controversial, and there’s not yet enough evidence to substantiate it.


Whether it's replacement or not is a matter of definitions. There's not enough evidence to really substantiate anything when it comes to exogenous testosterone in elderly men and that's what the studies claim, too. The adverse effects need to be addressed and it's not currently known whether the benefits outweigh the drawbacks. I recalled wrong about the cardiovascular stuff in the elderly which was milder than i thought, the adverse effects were more like prostate cancer and overgrowth etc, but you get the point i guess?

In young men, the benefits never outweigh the drawbacks is my point, because the benefits seen in the elderly are the normal traits that are expected to be seen in young males. This means that from a health perspective any extra testosterone (or analogues) is only increasing the risk of adverse effects in young males. By how much? That i don't know other than it being enough to justify advising against it from a health perspective. Any personal decision to accept the risks to gain relative benefits (such as landing a movie role, winning a bodybuilding competition, gaining advantage in sports etc.) isn't really a part of this discussion. I'm only talking about the risks.

This post was edited by Neptunus on May 21 2019 03:40am
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May 21 2019 07:46am
Quote (Neptunus @ May 21 2019 09:37am)
Whether it's replacement or not is a matter of definitions. There's not enough evidence to really substantiate anything when it comes to exogenous testosterone in elderly men and that's what the studies claim, too. The adverse effects need to be addressed and it's not currently known whether the benefits outweigh the drawbacks. I recalled wrong about the cardiovascular stuff in the elderly which was milder than i thought, the adverse effects were more like prostate cancer and overgrowth etc, but you get the point i guess?

In young men, the benefits never outweigh the drawbacks is my point, because the benefits seen in the elderly are the normal traits that are expected to be seen in young males. This means that from a health perspective any extra testosterone (or analogues) is only increasing the risk of adverse effects in young males. By how much? That i don't know other than it being enough to justify advising against it from a health perspective. Any personal decision to accept the risks to gain relative benefits (such as landing a movie role, winning a bodybuilding competition, gaining advantage in sports etc.) isn't really a part of this discussion. I'm only talking about the risks.



Completely anecdotal of me, but there are a VAST amount of ex athletes and other healthy individuals who have an incredible level of health while being on TRT.

Few things about them though is that their natural test levels were low prior to beginning treatment, and typically their serum levels are brought into the therapeutic window “the high end, duh” and they are monitored by an endocrinologist. They also eat like gods and work out 3-5 times a week. There are plenty of contributing factors to high morbidity in exogenous test usage, but the evidence against trt is based on the fat sloppy middle aged man who has ED and bitch tits.
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May 21 2019 11:02am
im still alive.
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May 22 2019 06:10pm
Quote (Neptunus @ May 21 2019 07:37pm)
Whether it's replacement or not is a matter of definitions. There's not enough evidence to really substantiate anything when it comes to exogenous testosterone in elderly men and that's what the studies claim, too. The adverse effects need to be addressed and it's not currently known whether the benefits outweigh the drawbacks. I recalled wrong about the cardiovascular stuff in the elderly which was milder than i thought, the adverse effects were more like prostate cancer and overgrowth etc, but you get the point i guess?

In young men, the benefits never outweigh the drawbacks is my point, because the benefits seen in the elderly are the normal traits that are expected to be seen in young males. This means that from a health perspective any extra testosterone (or analogues) is only increasing the risk of adverse effects in young males. By how much? That i don't know other than it being enough to justify advising against it from a health perspective. Any personal decision to accept the risks to gain relative benefits (such as landing a movie role, winning a bodybuilding competition, gaining advantage in sports etc.) isn't really a part of this discussion. I'm only talking about the risks.


shooting up old fellas with some test would probably eliminate death from falls almost entirely, and encourage exercise because u'd feel like less of a weak old fuck, on that basis alone i think i will do it when im old

can u imagine if arnold wasn't still strong with invincible roid bones? we might'd been seeing a different type of headline after that african guy dropkicked him from behind the other day

This post was edited by Dominate2 on May 22 2019 06:10pm
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May 22 2019 09:06pm
Quote (Dominate2 @ May 23 2019 12:10am)
shooting up old fellas with some test would probably eliminate death from falls almost entirely, and encourage exercise because u'd feel like less of a weak old fuck, on that basis alone i think i will do it when im old

can u imagine if arnold wasn't still strong with invincible roid bones? we might'd been seeing a different type of headline after that african guy dropkicked him from behind the other day


he wouldn't have been on the news.
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May 22 2019 11:44pm
Quote (ozzyarmy3 @ May 21 2019 03:46pm)
Completely anecdotal of me, but there are a VAST amount of ex athletes and other healthy individuals who have an incredible level of health while being on TRT.

Few things about them though is that their natural test levels were low prior to beginning treatment, and typically their serum levels are brought into the therapeutic window “the high end, duh” and they are monitored by an endocrinologist. They also eat like gods and work out 3-5 times a week. There are plenty of contributing factors to high morbidity in exogenous test usage, but the evidence against trt is based on the fat sloppy middle aged man who has ED and bitch tits.


I assume you should know that anecdotes aren't to be taken too seriously without accounting for the real numbers and all the possible biases. The evidence against TRT is just the general information we have on androgen abusers, but toned a bit down.

Quote (Dominate2 @ May 23 2019 02:10am)
shooting up old fellas with some test would probably eliminate death from falls almost entirely, and encourage exercise because u'd feel like less of a weak old fuck, on that basis alone i think i will do it when im old

can u imagine if arnold wasn't still strong with invincible roid bones? we might'd been seeing a different type of headline after that african guy dropkicked him from behind the other day


We don't have enough studies. Your premise is plausible but most we can do is to study it more. We aren't sure that we will eliminate fall deaths more than we would increase negative cardiovascular events or prostate cancers. I searched for studies and i found conflicting evidence on the benefits vs. drawbacks. Mind you, exercise is a good way of maintaining activity levels without the drawbacks.

This post was edited by Neptunus on May 22 2019 11:49pm
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May 23 2019 06:59am
Quote (Neptunus @ May 23 2019 05:44am)
I assume you should know that anecdotes aren't to be taken too seriously without accounting for the real numbers and all the possible biases. The evidence against TRT is just the general information we have on androgen abusers, but toned a bit down.



We don't have enough studies. Your premise is plausible but most we can do is to study it more. We aren't sure that we will eliminate fall deaths more than we would increase negative cardiovascular events or prostate cancers. I searched for studies and i found conflicting evidence on the benefits vs. drawbacks. Mind you, exercise is a good way of maintaining activity levels without the drawbacks.



Anecdotes are still evidence in some cases, I just don’t have the platform to start a massive study on the benefits of trt, nor do i care enough to dig up the case studies that support this “it wouldn’t be a viable option in the aging community if there weren’t clear cut benefits behind treatment”.

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May 23 2019 10:56am
Quote (ozzyarmy3 @ May 23 2019 02:59pm)
Anecdotes are still evidence in some cases, I just don’t have the platform to start a massive study on the benefits of trt, nor do i care enough to dig up the case studies that support this “it wouldn’t be a viable option in the aging community if there weren’t clear cut benefits behind treatment”.


They are, but anecdotes and case studies place low because of their susceptibility to bias. Medical guidelines can't be made on their basis only. If you can't start the study it doesn't mean you can make the claim. Physiology is a very deceiving field, even though one thing may seem like something at a small scale, it can be something completely else on the large scale. Because extensive TRT research hasn't been done and the adverse effects occur on a time scale longer than the benefits, the deceiving effect may be significant. More research needs to be done, until then we can only speculate and be better safe than sorry.
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May 24 2019 07:59am
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