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#21
Apr 4 2017 09:30am
Quote (Sunline @ Apr 4 2017 03:35am)
tell me more about how he will alter receptor sensitivity.


Quote
1)How much caffeine do you need to get going in the morning?

If your answer is one cup of coffee/tea or more, that’s too much. You shouldn’t need caffeine to create wakefulness. The ingestion of caffeine alters the brain’s ability to signal fatigue. Each molecule of caffeine closely resembles one of your brain’s byproducts of metabolism, adenosine. Over the course of a day, adenosine builds up within your gray matter and latches onto receptors that create eventual fatigue and signal your much needed rest. When consumed, caffeine dons its sheep’s clothing and sneaks into the adenosine receptors to prevent adenosine binding. With nowhere to go, the adenosine floats aimlessly, sadly wondering when it gets to go home. In response, the brain creates more adenosine receptors with the hope of accommodating both the caffeine and adenosine. Now you need more caffeine to create the same level of wakefulness. When you halt caffeine intake, adenosine hungrily binds to the newly available receptors and drags you into the depths of fatigue.

Let’s liken this to fatigue during your exercise routine. If your body couldn’t signal fatigue (read: your metabolism can’t keep up with your activity), you’d grind yourself into an eventual injury with the perception that all was well. Your brain signals to you at the end of every day that it needs rest and it will do so again in the morning if the requirement was not met. Many of us receive the signal and flip the proverbial bird with the tip of a coffee mug.


In between classes and short on time so I'll just quote this to get the general idea across. There's a reason why one cup of coffee no longer does it for you like it did the first time you drank coffee.
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#22
Apr 4 2017 11:10am
Quote (Braxton11 @ Apr 3 2017 04:10pm)
Depends on your definition of fine.

Will he die from it? No.

Will he alter the sensitivity of the receptors, thus changing the phsyiology? Yes


.. lol everything technically changes your physiology in some way insofar as it is an experience, and thus neural changes manifest.

But yes, tolerance will accrete to caffeine. No, that doesn't mean it's that bad. Everything is homeostatically driven so that's really a given.

Quote (duffman316 @ Apr 3 2017 11:12pm)
Got some sound medical advice via pms, should be good now, can close thread ^_^

Basically water can offset any issues for the kidneys and it's just heart problems of have to watch out for.


Again, the "kidney issues" aren't a real issue anyhow. The diuretic effect is mild, ephemeral, and at the whims of tolerance as well. The heart issue is, well, almost assuredly a non-problem. Maybe some weak links in certain susceptible individuals but that's all.
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#23
Apr 4 2017 12:36pm
Quote (Balla @ Apr 4 2017 12:10pm)
.. lol everything technically changes your physiology in some way insofar as it is an experience, and thus neural changes manifest.

But yes, tolerance will accrete to caffeine. No, that doesn't mean it's that bad. Everything is homeostatically driven so that's really a given.



Again, the "kidney issues" aren't a real issue anyhow. The diuretic effect is mild, ephemeral, and at the whims of tolerance as well. The heart issue is, well, almost assuredly a non-problem. Maybe some weak links in certain susceptible individuals but that's all.


LOL jesus christ
you provide no evidence and refute huge claims...how far up your ass is your head? or is it up someone else's ass???????

This post was edited by Bubbler on Apr 4 2017 12:37pm
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#24
Apr 4 2017 01:13pm
Quote (Braxton11 @ 4 Apr 2017 16:30)
In between classes and short on time so I'll just quote this to get the general idea across. There's a reason why one cup of coffee no longer does it for you like it did the first time you drank coffee.


I'm well aware there's a reason, I was curious about the specific mechanism.

That quote sounds way too simplistic in explaining central fatigue, but interesting nonetheless, thanks.
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#25
Apr 4 2017 03:28pm
overuse concerns with caffeine should probably be associated with sleep deprivation and potential adrenal fatigue/endocrine fuckery, but all of that depends on tolerance, dosage, and timing

4 c/d is on the heavy side but i doubt it's going to do anything to your kidneys

i just never saw why anyone would need that much coffee
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#26
Apr 5 2017 10:44am
Quote (Bubbler @ Apr 4 2017 02:36pm)
LOL jesus christ
you provide no evidence and refute huge claims...how far up your ass is your head? or is it up someone else's ass???????


What I speak is basic physiology
can link you to numerous books/articles if you wish, though. I'm all about percolating truth and understanding, thus anytime I can either edify someone myself or, even better (as it's longer lasting), galvanize them to do it themselves, it's a win. PM me if you wish.
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#27
Apr 5 2017 11:33am
Quote (Bubbler @ Apr 4 2017 01:36pm)
LOL jesus christ
you provide no evidence and refute huge claims...how far up your ass is your head? or is it up someone else's ass???????


Rip, arguing with somebody in med school m9

Actually I'm not sure you even argued. lol

This post was edited by tommyd323 on Apr 5 2017 11:33am
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#28
Apr 5 2017 11:36am
Quote (tommyd323 @ Apr 5 2017 01:33pm)
Rip, arguing with somebody in med school m9

Actually I'm not sure you even argued. lol


lolol
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#29
Apr 5 2017 12:58pm
Quote (Balla @ Apr 4 2017 12:10pm)
.. lol everything technically changes your physiology in some way insofar as it is an experience, and thus neural changes manifest.

But yes, tolerance will accrete to caffeine. No, that doesn't mean it's that bad. Everything is homeostatically driven so that's really a given.



Again, the "kidney issues" aren't a real issue anyhow. The diuretic effect is mild, ephemeral, and at the whims of tolerance as well. The heart issue is, well, almost assuredly a non-problem. Maybe some weak links in certain susceptible individuals but that's all.



I was afraid someone was going to call me on that since I generalized it way too much.

Sure physiology changes from simply eating a piece of food, moving, etc.

The point I was trying to convey was that it's a process similar to insulin receptor sensitivity and the progression of type 2 diabetes in terms of changing physiology and not just regular changes of physiology. Definitely should have elaborated more, but was short on time and I forget that not everybody is at the same level.

It's not bad in terms of 4 cups a day will kill the guy, but it's not exactly good either. It could have a tremendous impact on other factors of daily living for him.
Quote (Sunline @ Apr 4 2017 02:13pm)
I'm well aware there's a reason, I was curious about the specific mechanism.

That quote sounds way too simplistic in explaining central fatigue, but interesting nonetheless, thanks.



Sorry if I came off as a dick. Was extremely short on time. The quote is actually from the DPT that has been kind of like my mentor.

The idea is that you have receptors for plenty of molecules in the body, whether it's calcium, insulin, etc. If you alter your body where your receptors are useless and you still have the molecules looking to do their task, your body is going to create a way to let them do just that at the current time and not care about the consequences down the road.

Quote (tommyd323 @ Apr 5 2017 12:33pm)
Rip, arguing with somebody in med school m9

Actually I'm not sure you even argued. lol



Be careful when just assuming someone in med school knows what they're talking about.

Not knocking Balla as he seems to be pretty well educated on numerous topics.

This post was edited by Braxton11 on Apr 5 2017 12:59pm
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#30
Apr 5 2017 06:02pm
Quote (tommyd323 @ Apr 5 2017 12:33pm)
Rip, arguing with somebody in med school m9

Actually I'm not sure you even argued. lol


i am in medschool, rofl.

but RIP your mentality if you think that makes a difference, when this sort of knowledge is freely available and just takes some critical thinking to deduce the results

not all of us need to assuage our egos by sounding smart on a video gaming forum...i do that enough in the real fuken world...i come here to troll and relax.

additonally, what is more relevant to these sort of discussions if you actually understood them is your research background
i've published multiple first authors and numerous second authors in various fields, but who the fuck cares abt any of that when the name of this website has d2 in the title.

but which sf would blindly use "being in medschool" as a blank check to be right about everything? probably the group of the most insecure people in this whole forum (let's combine a place for nerds with a desire for physical perfection = sounds like a perfect fly trap for insecurity, rofl)

This post was edited by Bubbler on Apr 5 2017 06:12pm
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