Quote (Balla @ 17 Aug 2015 22:00)

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@OP 2 weeks on/off is fine. Or you could run it straight through a for upward of 4ish weeks by taking some ketotifen alongside it (at least for portions) which would help sustain adequate beta-2 adrenergic receptor expression.
You could also MAYBE get this effect via benadryl but it's not as studied, or at least documented in humans. Just theorycrafting predicated on its ability to inhibit phospholipase c.. or well, more likely via antagonizing the h1 receptor that's Gq coupled and thereby impede its activation, may sustain more Gs coupling through the beta-2 adrenergic receptor. I've also read random posts from people talking about phospholipid methylation via beta-2 agonism and thereby that causing subsequent downregulation via phospholipases.. but I've never been able to identify a study (or group of studies) tying that together. Because it's known that membrane/receptor methylation actually increases coupling of the beta-2 receptor to its major effector, cAMP. So that contention doesn't make much sense to me unless anyone has a more concrete study to show. Sorry for the nuance.