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Member
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Nov 10 2014 06:58pm
Any1 wan go see with me??
Member
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Nov 10 2014 07:04pm
Quote (Qwaze @ Nov 10 2014 07:58pm)
Any1 wan go see with me??


ill go bb
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Nov 10 2014 07:10pm
Quote (Deathslaya16 @ Nov 10 2014 06:04pm)
ill go bb


come together

right now

over me
Member
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Nov 10 2014 08:03pm
Lol
fucking stupid
saw Gary Taubes in there too.. oh lawd. That heavy bias
It is entirely the fault of the obese (apart from the rare aberrations with a genetic disorder) for their obesity.. you can't dismiss the blame and say it's the companies fault for it. That's egregious and dismissive of the problem.
This is kind of upsetting. It's just another method of finger pointing. Fat shaming is a good thing in this regard.
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Nov 10 2014 08:49pm
Quote (cloudkicker @ Nov 10 2014 11:53am)
Sugar intake isn't the problem. It's excess caloric intake with the absence of exercise. Sugar is entirely fine in non-exorbitant amounts when coupled with vigorous exercise.


^
Nicely said
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Nov 10 2014 08:56pm
I LOVE candy...I also understand that if I don't moderate my intake I will get fat and gross...therefore I moderate my intake..

...that cocaine to sugar comparison was cute though..
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Nov 10 2014 09:05pm
Quote (Afficionado @ Nov 10 2014 10:56pm)
I LOVE candy...I also understand that if I don't moderate my intake I will get fat and gross...therefore I moderate my intake..

...that cocaine to sugar comparison was cute though..


Yeah.

Cocaine hasn't made me fat no matter how much I take.
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Nov 10 2014 09:43pm
I'm not one that's completely for that type of food reward hypothesis of obesity, but it is a real thing.. I just don't think it's significant enough in a majority of the population.

High sugar foods definitely stimulate endogenous opioid synthesis, which increases dopamine signaling through the mesolimbic system leading to reinforcement of the behavior aka an "addiction" to eat, though I think that's where the overstatement begins. Notwithstanding, mu opioid receptor stimulation also increases food intake/hunger and increases palatability of foods. There's direct interaction between the NAc for instance, and regions of the hypothalamus that regulate satiety/hunger as well.
Again, I do think that's overstated overall.. I think this may actually happen for a small group of the population though. I'm sure simple reinforcement may play a quite subtle, but large role overall.

Nonetheless, if they really want to delve away from a thermodynamic model of obesity, other avenues are imo at least more likely & significant, such as chronobiology, the gut microbiome, inflammation, leptin resistance, etc. Though these are still secondary to thermodynamics. Honestly they could probably all amalgamate and figure things out much better.

In general, it would go in a a fashion somewhat like initially a slight reinforcement in food intake via highly palatable foods, leading to slow fat accretion --> alters gut microbiome and alters intestinal permeability allowing more LPS to pass through, causing systemic inflammation --> stimulates a lot more leptin, chronically, leading to initial vagal afferent leptin resistance --> cross talk with other pathways causes increased resistance to other satiety hormones acting at the vagal afferents, causing further decreased satiety and more hunger --> hypothalamic leptin resistance sets in, which also causes reciprocal insulin resistance via signal transduction cross-talk --> you're fucked
Chronobiology could fit in any category to speed things up, depending on the person's habits.
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Nov 10 2014 10:21pm
Inb4 ThomasPaine (or w/e his new name is) : better listen to this advice because it might just save your life https://www.youtube.com/watch?v=ZCMC4J8wqOw
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Nov 10 2014 10:39pm
Browsing the comments and see a power lifter icon.

Check out the person.

It's Aube. lol
https://www.youtube.com/user/trickspk3r
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