Quote (Lightman @ Jan 28 2014 02:52am)

Is there a research correlating it with deprived sleep?

Quote (Lightman @ Jan 28 2014 02:52am)

Is there a research correlating it with deprived sleep?

Quote (Balla @ Jan 28 2014 06:45pm)

I would still like to see some studies done on that though. Several trials using probably the same group of people. Memory and other cognitive tests while fasted with high ghrelin, and after feeding and thus low ghrelin. Do it several times and see if statistical significance is reached

Quote (Balla @ Jan 27 2014 10:38pm)

I was researching ghrelin and found this interesting. Apparently it's implicated in memory and learning via acting at the hippocampus, apart from its usual effects at the hypothalamus.


http://www.nature.com/neuro/journal/v9/n3/abs/nn1656.html
http://www.sciencedirect.com/science/article/pii/S0006291X02027407
http://www.sciencedirect.com/science/article/pii/S0006291X03025531?np=y
http://www.sciencedirect.com/science/article/pii/S0031938410001848
http://www.sciencedirect.com/science/article/pii/S1471489207001804?np=y
http://www.sciencedirect.com/science/article/pii/S0196978110000938
http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2010.07491.x/abstract;jsessionid=3CB7D88B72E3E717BE7F6C768FC1AF7C.f01t01?deniedAccessCustomisedMessage=&userIsAuthenticated=false
http://www.ncbi.nlm.nih.gov/m/pubmed/24367106/?i=3&from=ghrelinandmemory



I'm hoping to say it's a safe extrapolation that while circulating ghrelin levels are high, it will facilitate learning to a greater degree. If this is true, probably another benefit for IF protocols. Combined with slightly increased sympathetic output while fasting (ghrelin is also sympathetically innervated), thus increased mental acuity and etc. Just seems pretty interesting, but doubtful the difference is actually too significant.

Quote (Balla @ Jan 29 2014 05:36pm)

Just more random shit lol
I hope nobody minds

I was wondering why sympathomimetics (ephedrine, Clen, etc) potentiate the effects of caffeine and well vice versa.
I thought at first it'd be due to adenosine receptor antagonism (affects thermogenesis, heart rate and such). Apparently though, it's the phosphodiesterase inhibition caffeine provides that does it (inhibiting that = increased cAMP levels). Interesting to me I guess

Quote (ThomasPaine @ Jan 29 2014 06:38pm)

Interesting to blue pills users lol

Quote (Balla @ Jan 29 2014 05:48pm)

Wot
Blue pill would be blissful ignorance? Am not understanding