Quote (IAm_Carnage @ Aug 20 2012 07:11pm)
Your inbox is full so I can't reply. But yes I am good with that
emptied.
Quote (sven00100 @ Aug 20 2012 08:39pm)
Hey, Raynor,
This question is mostly out of curiosity, so if you don't know or don't want to explain, I'll be perfectly fine. Haha
I was thinking about ketosis, as I don't want to be trying to figure out a new diet from scratch while I'm in pharmacy school if I switch over, and I was wondering about the avoidance of citric acid.
My basic question is: why does citric acid "throw you [from] ketosis?"
It's possible that it has just been shown, and the explanation is mere conjecture, but I thought I would ask in case you knew.
Even as far as conjecture my understanding is limited.
You could replenish NADH+ and GTP, where the GTP could be converted to ATP by Nucleoside Diphosphokinase, but I would guess that without another incoming source of energy, oxaloacetate would hinder the forward reaction in a short time. Compared to even the near zero intake of carbs, this would seem like a very limited source of energy. . . so I doubt my conjecture there accounts for anything.
I guess I don't have any idea if the body uses citric acid as a signalling molecule. I suppose it could be an early indicator of incoming products from glycolysis. . .
I also don't really know if it's related to glycolysis or gluconeogenesis.
Anyways, enough of me ranting. It's not helping with my question. I was just curious if you knew, or had a reasonable explanation as to why citric acid would have such an effect.
Thanks again, Raynor
~Steven
Excellent question.
Regarding ketosis, the citric acid question is more of a hindrance from entering Deep Ketosis, than throwing a person out of deep ketosis. Essentially, it can take up to a week to get into deep ketosis, which is why I advise a carb day every 2 weeks rather than every 1 week. Obviously, exercise level and intensity as well as overall liver health have a lot to do with how fast someone enters ketosis. Assuming you are 30% into ketosis and nearing the moderate phase, and you consume citric acid, you run the risk of preventing your body from continuing into deep ketosis and thus the carb day will then come too soon, repeating itself a viscious cycle where true ketosis is never achieved for any sustained period of time. The reason for the citric acid preventing the body continuing into ketosis has to do with citric acid activating the Krebs cycle (citric acid cycle) and thus leading to gluconeogenesis
HOWEVER -
The studies have shown that only SOME subjects were kicked out of ketosis, or rather prevented from going into deep ketosis by consuming citric acid. Others were absolutely fine with it. This is a person-to-person anomaly that can NOT be explained (yet).
My advice is always to stay away from the citric acid in order to ensure total ketosis without incident, in case you do happen to be one of the people who is affected negatively by its consumption.