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Dec 30 2013 07:08pm
Quote (Balla @ Dec 30 2013 10:37pm)
http://www.salon.com/2013/12/29/sciences%5Fobsession%5Fthe%5Fsearch%5Ffor%5Fa%5Fsmart%5Fpill/

Interesting
Nicotine is the best cognitive enhancer?
A few quotes from the article I found interesting:

"That same study, like many others, found that other ingredients in tobacco smoke are necessary to amp up nicotine’s addictiveness. Those other chemical ingredients — things like acetaldehyde, anabasine, nornicotine, anatabine, cotinine, and myosmine — help to keep people hooked on tobacco. On its own, nicotine isn’t enough."

“The cognitive-enhancing effects of nicotine in a normal population are more robust than you get with any other agent. With Provigil, for instance, the evidence for cognitive benefits is nowhere near as strong as it is for nicotine.”

"at least nicotine certainly looks safe. And we’ve seen absolutely no withdrawal symptoms. There doesn’t seem to be any abuse liability whatsoever in taking nicotine by patch in nonsmokers. That’s reassuring.”

"Have published over a dozen studies showing that in animals and humans alike, nicotine administration temporarily improves visual attention and working memory."

"nicotine increases something called prospective memory, the ability to remember and implement a prior intention."

"the irony gets mad deep — the one purpose for which nicotine patches have proven futile is the very same one for which they are approved by the Food and Drug Administration, sold by pharmacies over the counter, bought by consumers, and covered by many state Medicaid programs: quitting smoking."



Obviously I'm not going to start using nicotine now haha, I'd like to see some long term studies on addiction and adverse effects, but nonetheless, it's quite interesting.

e:
http://examine.com/supplements/Nicotine/
http://www.gwern.net/Nicotine


wow, very cool, thanks for posting.
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Dec 30 2013 07:16pm
http://simplesciencefitness.com/


This website should go in the sticky.

Obviously the diet portion is a big generalized versus IIFYM.

This post was edited by xGeArz on Dec 30 2013 07:18pm
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Dec 30 2013 07:37pm
Quote (xGeArz @ Dec 30 2013 08:16pm)
http://simplesciencefitness.com/


This website should go in the sticky.

Obviously the diet portion is a big generalized versus IIFYM.


Caffeine counteracts creatine absorption?

http://www.ncbi.nlm.nih.gov/pubmed/8929583
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Dec 30 2013 07:43pm
Quote (ChrTal @ Dec 31 2013 01:37am)
Caffeine counteracts creatine absorption?

http://www.ncbi.nlm.nih.gov/pubmed/8929583


http://www.ergo-log.com/creatinecaffeine.html

Yeah some studies suggest that.

Be sure to note that these studies are using 400mg + of caffeine.....and a standard cup of coffee has 50-100mg usually.
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Dec 31 2013 01:10am
Quote (xGeArz @ Dec 30 2013 08:45pm)
I was about to post this today lol.


Hahaha very nice. I found this on reddit but thought it was pretty cool
great minds think alike ;)
also to the next page, cool site. Very simple, yet informative.

Also about nicotine, alot of people are suggesting even caffeine is more addictive than it lol. I'm stricken though, because of the typical connotation with nicotine I'm stuck with
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Dec 31 2013 07:22am
Quote (xGeArz @ Dec 30 2013 08:43pm)
http://www.ergo-log.com/creatinecaffeine.html

Yeah some studies suggest that.

Be sure to note that these studies are using 400mg + of caffeine.....and a standard cup of coffee has 50-100mg usually.


I did a little research on this last night before bed, it seems as if no one is really sure if caffeine affects creatine absorption.

Some articles suggest to use caffeine in the morning and creatine at night.. Voodoo/broscience? Or would separating intake actually be useful?
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Dec 31 2013 10:26am
Quote (ChrTal @ Dec 31 2013 09:22am)
I did a little research on this last night before bed, it seems as if no one is really sure if caffeine affects creatine absorption.

Some articles suggest to use caffeine in the morning and creatine at night.. Voodoo/broscience? Or would separating intake actually be useful?


http://www.ncbi.nlm.nih.gov/pubmed/21207054


ehhhh, fuck it, edit, on the subject of creatine I'll just post this too

http://link.springer.com/book/10.1007%2F978-1-4020-6486-9#section=190560&page=1

This post was edited by Balla on Dec 31 2013 10:30am
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Dec 31 2013 10:28am
Quote (ChrTal @ Dec 31 2013 01:22pm)
I did a little research on this last night before bed, it seems as if no one is really sure if caffeine affects creatine absorption.

Some articles suggest to use caffeine in the morning and creatine at night.. Voodoo/broscience? Or would separating intake actually be useful?


Anecdotal evidence, I drink a shit ton of coffee in the morning and a cup before working out. Then I take creatine in the evening after lifting and I still can see the ergogenic benefits of creatine.
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Dec 31 2013 01:19pm
http://www.ncbi.nlm.nih.gov/pubmed/24105415?dopt=Abstract

Hmm this is intriguing and striking to me
The induction of NF-kB following TLR signaling in leukocytes leads to the expression of inflammatory genes and prod. of cytokines like TNF, IL1, & IL6.. which are very pro-inflammatory
so the fact overexpressing NF-kB ameliorates atherosclerosis is strange to me
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