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Dec 17 2014 02:40pm
There is some evidence that the pump may be anabolic, though in practice I'm not sure how much this specific mechanism matters in the big picture.

To delve into it slightly, basically the metabolites accrete due to anaerobic pathways and act as osmolytes. This causes hyperhydration of the tissue, promoting increased protein synthesis via mTOR & ERK pathways and attenuated proteolysis. There's also some evidence this may act to promote increased satellite cell kinetics. It can be simplified to the fact that your cells sense the hyperhydration and discern it as a threat to general cellular integrity, similar to metabolite accretion in general, cascading to anabolic & survival pathways.

Quote (Afficionado @ Dec 17 2014 11:04am)
do yourself a favor and don't listen to rich about anything.


And this most always

This post was edited by Balla on Dec 17 2014 02:41pm
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Dec 17 2014 02:59pm
Quote (Lightman @ Dec 17 2014 08:02pm)
It also means morons love to hear bullshit.


who are you calling a moron?

Quote (Balla @ Dec 17 2014 08:40pm)
There is some evidence that the pump may be anabolic, though in practice I'm not sure how much this specific mechanism matters in the big picture.

To delve into it slightly, basically the metabolites accrete due to anaerobic pathways and act as osmolytes. This causes hyperhydration of the tissue, promoting increased protein synthesis via mTOR & ERK pathways and attenuated proteolysis. There's also some evidence this may act to promote increased satellite cell kinetics. It can be simplified to the fact that your cells sense the hyperhydration and discern it as a threat to general cellular integrity, similar to metabolite accretion in general, cascading to anabolic & survival pathways.


Would this apply to guys on steroids to a greater extent than nattys though?
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Dec 17 2014 03:20pm
dumb as fk. disregard everything he say in this vid
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Dec 17 2014 03:26pm
He says his natty vs steroid training

Pump will mostly help while on roids only

Useless while off
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