I've read it.

At least he gets it done, it works for him. Some people just need essentially a bible to follow.

Up

Lol

Tbh I'm trying to start REALLY delving into our endogenous gut microbiome, just fukn busy with this semester. It seems to ostensibly have robust implications for our health..
I'm trying to figure out what foods, food types, etc have deleterious effects on the levels, diversity, or actual quality of our gut bacteria. I think it MAY play a larger role than many think, or at least I've previously thought. I need to find out how significant these changes are though.

For instance, "bad" pathogens in our gut via certain foods will increase the systemic levels of LPS markedly via infiltrating from the brush border, which then causes inflammation.. and amongst other things elevates leptin. If leptin becomes elevated enough to induce SOCS3, tissues, particularly the hypothalamus may begin becoming leptin resistant, which could then cascade to hyperphagia, then subsequent obesity, etc. Amongst other things, glucose can directly induce SOCS3 signaling and very high fat diets as well as fructose can also increase the systemic LPS levels by quite a lot. There's also a lot of links here with depression and cognitive function due to cytokine elevation.

I don't want to give too much credence here just yet, nor delve into the nuances unnecessarily yet, but it may be a big player actually.

IIRC there's new information coming out claiming that gut bacteria does have a pretty high relevance for a lot of other general problems and diseases

Exactly what I'm getting at without going too far
I understand the mechanistic insight. My knowledge of neuroscience is helping me understand it with celerity in terms of BBB permability, oxidative stess, microglia and cytokine output influencing fatigue, depression, cognition, etc.. and effects on other facets.

I just need to dial in on: how significant of a shift does the increased brush border permeability and LPS increase make? Or maybe it's insignificant acutely but if persisted becomes noxious? That would be akin to so many things deemed safe ofc.
Also need to dial in the exact contribution of different foods to the different constituent microbiome present.. that'll take awhile I think.

from what i've seen of Layne he is a flexible dieting advocate.

I wonder how commensal bacteria that assists in digestion, synthesis of vitamins, and immunity causes diseases...must be a big lie. Proof of this?

i dont think hes saying theres a causal relationship between microbiome and disease, but rather that microbiome diversity is relevant to our understanding of certain disease processes, and bacterial flora can have a significant impact on overall health

Are we referring to pathogenic "gut" bacteria or commensal flora?