Any research/input on this?

any overdose of anything destroys something

Nah Brazilian aboriginies eat cacao by the bushels and it has caffeine + theobromime and they live 105+ yrs avg

Gobbledygook.

Besides, caffeine hardly stimulates neural NE release unless taken in considerably high doses
The impact of adrenal medullary EPI release due to caffeine is mostly based on SNS signaling NE + a slight rise in Ca2+ causing release
Adrenal fatigue is pseduoscience anyway. Most causes of chronic fatigue syndrome and related issues with the adrenal system are a dysfunction of the entire HPA axis and generally originate from a lack of neural drive.

Boom. But a big excess of caffeine might toy with your posterior pituitary and the levels of vasopressin in your body, but that's just a temporary side effect, if that's what you were referring to OP.

And even then, the effect on vasopressin is only a secondary effect due to the afferent arteriole dilation to the nephron, which will decrease renin, which decreases angiotensin II, which decreases aldosterone.. and the decreased aldosterone manifests as a decreased vasopressin. I doubt he's referring to that, as it has no bearing on the adrenals

It has an indirect bearing on the adrenals as the fluctuations in vasopressin and aldosterone levels might cause a bit of stress on the body causing the adrenals to work a bit more, but in no way is it enough to destroy them lol
Very insignificant effect on top of what you mentioned, but again, it has to be a pretty big excess of caffeine to have this effect

This post was edited by Mesonychid on Aug 11 2014 04:21pm

I've seen some stuff that points to a drain on the adrenals but generally speaking the recovery will make the drain mostly meaningless (see the details above).

What I was going to add is that if you have any concerns about your adrenals, look into supplementing with kelp, dulse, or anything with reasonably high levels of iodine. You can go see a doctor for a referral if you feel like there's a bigger problem afoot.

The "mystery" behind the big concern about adrenal deficit is just that a lot of people take too much caffeine too often, and what's really happening is that they're tiring the crap out of themselves, not draining their adrenals to nothing. This is why you see coffee drinkers needing coffee to fuel up. It's more of a physical dependency than anything, and it's about a little high and, more importantly, energy. Energy drain is the issue (and perhaps CNS smashing, which depends more on activity than anything), not adrenal drain.

Rest and sleep solve this problem.

This post was edited by RewtheBrave on Aug 11 2014 04:26pm

Well, as vasopressin stimulates CRH/ACTH release, that would actually cause a decrease in the amount of "work" the adrenals need to do.
And yup. It takes a lot of caffeine to even really cause many of these changes to a noteworthy degree

@OP/topic, peep this paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046013/

the introduction says: "Adrenal insufficiency is a relatively rare disease. Primary adrenal insufficiency has a prevalence of 90–140 per million, and the estimated prevalence of secondary and tertiary (central) adrenal insufficiency is 150–280 per million."

Given the ubiquity of caffeine/coffee, I'd say the chance for them to cause this adrenal problem is virtually 0%.

Or 100% if you ask a Naturopath.

Lul.