Before starting a character, ask yourself what you want from it.
Do you want a character that will clear bosses and farm charms/fragments from bosses,
or do you want character that will farm high density high level areas for Super Sacred Uniques, Xis runes etc? (eg Duncraig, Fauztville, Torajan Jungle)
I haven't tried many builds, but I tried:
Summoner Barb, amazing for solo gameplay as it clears pretty well. Gets boring as you're doing nothing but spaming summons that are both your damage and your meat shield.
Melee Nec, amazing for clearing areas such as Fauztville
Wolf druid, same like melee nec but has a messy animation in which every spell cast (teleports on target and spawns 1000 ravens that kill everything on screen) skips an animation frame and gives u 0.1 second of nasty black screen. Dno if they patched it.
Bowzon, absolutely my favorite char. Debatable #1 farming character, and with some safe gameplay it can possibly clear every boss ingame too. Squishy at start, but becomes a fkn beast late game.
Maelstorm assassin, similar to bowzon. Better survivability but less damage. Maelstorm is like vanilla d2's multiple shot that casts in all directions.
There are some builds like poison barb which seem to be quite effective with cheap eq. Haven't tried it myself but I think
did so he can give you an input on that one
To be honest, Median is by far my favorite mod, as it gives so much new content u feel like you're playing a new game which is dope af.
Sadly, I'm so busy with real life for past few months that I barely have any time to play it.