whats best moovz for mewtwo and item to hold?

Shadow Ball
Thunder
Ice Beam
Fire Blast

Holding Life Orb

Having a poke on team with wish is ideal so u can switch out low mewtwo and pop back in nearly/completely full.

any other ideas?

if you want coverage, go for something like:

Thunder/Thunderbolt
Ice Beam
Aura Sphere
Shadowball/Fireblast

psychic because he gets a 1.5x boost because he's a psychic type making psychic 135 as its power.
ice beam
shadow ball and aurasphere for dark types.

4th gen:
Calm Mind
Ice Beam
Aura Sphere
Thunder
Leftovers

3rd gen:
Calm Mind
Ice Beam
Thunder Bolt
101hp sub
Leftovers

Fireblast for coverage is all sorts of useless. True story. The only pokemon in OU to be wary of is a scizor, really.

well yes, fireblast is for steels like Scizor and Metagross, because they tend to tear Mewtwo to shreds if they can get in on an Ice Beam or CM

and I wouldn't recommend Psychic, even though it is STAB, you are just asking to be killed by something like Scizor, Tyranitar or Metagross

This post was edited by Cowthang on Mar 27 2010 07:27am

The move psychic is a STAB, yes.
However, just like grass knot, in UBERs, too many mons resist or are immune to it (for psychic).
You should go read up smnogon