Tried to download Ghosts and it was successful.

Went to play it, and the first screen came up right, then there was a guy with a mask and it seemed to be loading fine.

Then after that screen, it just goes blank. Nothing happens.

I tried re installing it twice, but every time I try to play, the same thing keeps happening. Anyone know the solution?

Might get better luck here:
http://forums.d2jsp.org/forum.php?f=66

There seems to be some posts about it.

True, just not sure if it's a game issue or a console issue. The same disc works on my brother's xbox and other games work fine on mine.

Confused on what can be wrong

A lot of people seem to be having problems with Ghost on the XO. So long as other games work I wouldn't worry too much.