El - First and practialy useless rune, it can be usefull at start of the game to cube 3 of them into Eld runes
Eld - can be usefull in early stage of game if you place 3 of them into large shield for additional % block chance or in some cases to socket her into high end shield for better block if you have enough resistances
Tir - really great for leveling new characters if you socket bunch of them in your equip as they will grant you mana back for kills.
Nef - not very usefull rune, but can some people can buy them from you in stacks as they are used for crafting
Eth - not a usefull rune, other than being part of some low level runewords
Ith - usefull for low level characters and mercenaries as Ith in weapon provides +9 maximum damage, also could be sometimes sold in stacks for people who do crafting.
Tal - Tal is part of several very usefull Runewords people are making at early stages of game. Also used in crafting and recipes in horadric cube recipes for Item
upgrading and socketing white/ethereal items. Tal can also provide solid bonus to poison resistance in armor helm and shield.
Ral - Ral is part of several very good Runewords people are making at early stages of game and very usefull for cube recipes and crafting recipes. Ral can also
provide solid bnous to fire resistance in armor helm and shield. Ral can be used in cube to repair and recharge armor.
Ort - Ort is part of several very good Runewords people are making at early stages of game and very usefull for cube recipes and crafting recipes. Ort can also
provide solid bnous to lightning resistance in armor helm and shield. Ort can be used in cube to repair and recharge weapons.
Thul - Thul is part of several very good Runewords people are making at early stages of game and very usefull for cube recipes and crafting recipes. Thul can also provide solid bonus to Cold resistance in armor helm and shield.
Amn - mostly wanted to make runeword Spirit. Amn rune adds life leech if it is socketed in weapon which is very usefull for melee characters or to improve ACT II mercenary survivability. Amn is also used for some crafting.
Sol - mostly wanted because Sol is used for Insight runeword, also used for upgrading of unique items in cube. Sol can provide some physical damage reduction when socketed in items.
Shael - used for upgrading unique items and often used in weapons to increase attack speed. Shael can also increase faster block rate in shield and faster hit recovery in armor and Helm.
Dol - pretty much useless rune, not worth socketing and not used for almost anything.
Hel - rune can lower requirement for your items if you socket it in them. Hel is mostly used in Horadric Cube recipe to destroy content of socketed items if you
no longer want the runes, gems or jewels placed there.
Io - another not very usefull rune. Io has use only in few runewords.
Lum - usefull to make runewords Smoke and Lionheart and also used for upgrading unique weapons in horadric cube.
Ko - used for upgrading unique armors to elite version in horadric cube.
Fal - Not very usefull rune, but has use in great runeword Lionheart.
Lem - used for upgrading unique armors to elite version in horadric cube, but mostly wanted for nice % gold find bonus when inserted into socketed items.
Pul - first rune which is considered more valuable and traded more frequently for items as currency. Pul is the first rune which can be upgraded into higher rune with just two of them. Pul is also used in Horadric cube recipe to upgrade unique weapons to elite version.
Um - used as currency for buying and selling, very usefull for placing into socketed Armor/helm/shield for all resistances and into weapons for Open wounds.
Mal - used as currency for buying and selling, usualy not worth placing in socketed items but it can help in weapon to provide prevent monster heal or in armor/helm and shield to provide magic damage reduction. Its usualy better to sell Mal instead of placing it in items.
Ist - great rune and best amongst the mid runes. Used as currency and also frequently used into socketed items for additional magic find bonus.
Gul - highest mid rune, but pretty much useless for using and only works as currency to buy and sell items. Gul is usualy being upgraded with one more into Vex.
Vex - Vex in on the edge between mid and high runes. Can be used into socketed shield in rare cases, mostly by players who do PvP. Vex is commonly used for highly used runeword Heart of the Oak and as currency to buy better items.
Ohm - used to buy and sell highly valuable items, commonly used for runeword Call to arms. Ohm also adds +50% damage in weapon so she is sometimes used by more rich players to increase damage on some special socketed rare or unique items.
Lo - used to buy and sell highly valuable items, Lo is frequently used High Rune to make runewords Fortitude and Grief. Also can be socketed into weapon to provide
additional 20% deadly strike or +5 maximum lightning resistance into shield.
Sur - used to buy and sell highly valuable items. Less wanted than Lo and Ohm but still used in some runewords. Not worth socketing into iteams really.
Ber - used to buy and sell most valuable items, highly wanted Rune for top Runewords like Enigma or Infinity. Ber can be also socketed into armor/helm/shield for 8% damage reduction and into weapon for crushing blow, but thats rarely seen as rune itself is highly valuable for runewords or trading.
Jah - Most expensive high rune at start of season which can be used to buy most valuable items in game. Also is wanted for being part of Enigma runeword. It is possible to socket her into shield for +5% maximum life, but thats not worth doing because rune itself has so high value for trading or for making RW.
Cham - second most rare rune , but far from being valuable as Lo-Jah runes. Cham has very limited use in runewords, is used as currency for trading valuable items and can be used to get “cannot be frozen” in socketed items.
Zod - Most rare rune, used in trading and also being less valuable as Cham because of limited use of the rune in comparison to other high runes. Zod can be placed into socketed ethereal items to get Indestructibility property.