Yes, you can play on any reasonable size resolution on your desktop. Down to around 320x480, which is the smallest size supported (mobile), or as large as you want.
Just about all of the UI tweaks/changes needed apply to both mobile and desktop, so it makes sense to just do them both at the same time. The only things I plan to not complete for this release are:
- Landscape mode for mobile
- PvP
Some other mobile specific tweaks might not make it, but I'm not going to release a cobbled together port just to get it out sooner.
Here's what the town currently looks like. It also scales and looks/works great on mobile:
http://ladderslasher.d2jsp.org/ls_html5_2.png
I'm just wrapping up miscellaneous things at the moment. Release is getting closer.