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Genetically manipulating toxin-bearing phages, however, proved challenging, as cloning toxin genes can halt the growth of the bacterial host cells. To overcome this obstacle, Vandierendonck developed new cloning strategies in which toxin expression is tightly controlled at multiple levels. She also isolated phages from enterohaemorrhagic E. coli and characterized them both genetically and morphologically, including the identification of the bacterial receptors involved in infection.

As a proof of concept, she combined one of these phages with toxin genes and demonstrated in the laboratory that this recombinant phage could effectively kill the target bacterium via the toxin.

Quote (Masterbasians @ Nov 8 2025 01:02am)

colossal bioscience brought back some extinct species
direwolf's cool

Quote (powwpoww @ 8 Nov 2025 00:22)

I agree, it is cool. They're also working on mammoth and thylocene and some other stuff too.

Real life Jurassic Park type shit. It's a bad idea but it is cool.

Quote (Masterbasians @ Nov 8 2025 01:33am)

i thought it might be bad too
but then i thought about medicinal aspects
getting resources from past species offers a lot of speculative material