Have been off like 6 years, What are the fastest/best ways to make money these days ?

ED3 will net you a decent amount/hr with very good combat XP rates.
Getting some boss kills will unlock your bossing hub, go to the draynor lodestone and the entrance is nearby.
You can attune a portal in the boss hub to any boss you've killed at least once, allowing you to teleport directly there.

What are you current stats and gear? Can give you a better recommendation if I have that.

Really depends on your stats etc.
if high level then boss hunting for sure.
if lower level then some skilling might be a bigger boost for gp until you get higher level.

Hey, That ED3 does not say anything to me I have max melee skills, range 99, mage 99 also. Total +2100

ED3 = Shadow Reef. It's like a mini dungeon, the mobs give you dungeoneering exp, and drops.

Telos, aod, ed3, rad, rago all good gp/h

if skiller...

selling archaelogy materials
blood rune crafting
high lvl mining
buying stock from shops... can get ~4 mill a day just buying out item shop stocks and selling on GE

How much Gp/hour we are talking about with these ?

idk what your stats are

ranging from 4m/hr - 15m/hr with luck and RNG.