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Jan 14 2014 12:02pm
Post if you can do this.
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Jan 14 2014 02:14pm
Post em up. I could maybe tonight if I have time

Would be better if u just post
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Jan 15 2014 12:48am


This post was edited by Stolem on Jan 15 2014 12:53am
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Jan 15 2014 06:46am
The questions are really easy. You can read about each in 30 min on wiki or google.
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Jan 15 2014 09:44pm
11) you contain many B and T cells. these cells each have a specific receptor for a particular antigen. once a B or T cell binds an antigen, an activator will be able to then bind. This causes the cell to produce clones of the either B or T cell which retain a site that is still unique for the particular antigen. now, once cloned, the cells can either turn into plasma (effectors) or memory cells. effectors are what release the antibodies. memory cells have a much longer life than effector cells. they stay around and if the antigen becomes present again, you will get production of more effector & memory cells for that specific antigen. Due to the presence of these memory cells, this is why immunizations help out. the body is able to recognize the antigen much quicker/ on a larger scale and fight if off quickly.

also important is that after the first exposure, the cloned cells should all bind to the antigen, but their affinities to that antigen may be varied. Due to the variation in affinities for the antigen, specific clones will proliferate better than others and this also increases the response to the antigen. Generally when producing antibodies for industrial, they generally expose the animal to several doses of the antigen at different time points.

as for certain b/t cells with receptor for particular antigens found in the host body, i believe they are destroyed early on in development so they are not replicated and do not cause production of antibodies to the host.

12) they could acquire the immunity if they have TB, were given a TB vaccine, or were exposed in the past to TB. the body had developed memory cells that recognize TB or more specifically in the case of a skin test, the purified protein derivative which is administered.

/e for # 10, mucus/low ph should just pertain to creating environments that are not suitable for a great variety of infections agents. lysozymes target bacterial cell walls in general.

This post was edited by cialda on Jan 15 2014 09:47pm
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Jan 16 2014 12:45am
10) mucus pretty much just traps the microbial and and allows your cell-mediated response to kick in, and it's found pretty much in your respiratory tract and digestive tract and your reproductive tract. Mucus also contains digestive enzymes in it to fight microbes. it also contains dimeric IgA in it which you could write if depending on how your professor views "nonspecific antimicrobial effects"
low ph is found in the stomach, inside some cells like the granules of neutrophils, and even your skin. it pretty much provides an environment that is too harsh for the microbial to live in. it can also activate certain digestive enzymes and zymogens to digest the microbe.
lysozymes (which is also found in mucus), like cialda stated, disrupts bacterial cell wall integrity.

11) lots of B and T cells are made everyday. B cell development begins in the bone marrow where it'll undergo somatic mutation to develop a hypervariable domain that is specific for one type of antigen. before leaving the bone marrow, the B cell will undergo negative selection to get rid of the B cells with receptors that bind to self-antigen (aka autoreactive B cells). Once they leave the bone marrow, the naive, but mature B cell will travel and hopefully be recruited into secondary lymphoid organs. Inside the 2ndry lymphoid organs, if it binds to an antigen on it's b cell receptor, endocytoses the receptor and then expresses it on MHC I or II. This B cell will now be a professional antigen presenting cell and may form cognate interactions with a T lymphocyte that has survived positive and negative selection inside of the thymus to form a germinal center reaction and produce clones of itself. some of these progenies will become plasma cells like cialda stated, however, they'll only secrete only IgM since i'm going to assume that this is a primary infection. The rest of the progenies will undergo affinity maturation through somatic hypermutation and isotype switching through the expression of AID and generate new B cell receptors. These progenies will new receptors will compete with one another for a survival signal from the T cells (non-memory B cells do not survive very long). Of course, the progenies with receptors with higher affinity than the parent B cell will be "selected for" aka the clonal theory of selection.

tl:dr, you pretty much keep generating new B cells different B cell receptors. through somatic hypermutation and affinity maturation, you'll be able to generate and keep the ones with better affinity than what you started with, but you'll also weed out the ones that are autoreactive (aka fail negative selection at primary lymphoid organs)

12) pretty much what cialda said. ultimately, during a secondary immune response (which is how a vaccine works), you would've already had developed a B cell with a high affinity B cell receptor and a constant domain that isn't IgM whose progenies would've become a memory cell that circulates in your bodies or lining certain areas of your body such that when you become infected again, the memory cell will replicate and provide plasma cells that secrete the high affinity immunoglobulin right away. I forgot to mention before that developing this high affinity B cell receptor takes weeks to complete, so during a secondary immune response, you'll react a lot faster to the pathogen.
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Jan 16 2014 02:09pm
Explain the steps involved in bacteriophage DNA entering a bacterial cell.

last question.
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Jan 16 2014 03:19pm
Quote (Cyba @ Jan 16 2014 01:45am)
somatic mutation

opps, meant to say somatic recombination lol, not mutation

Quote (Stolem @ Jan 16 2014 03:09pm)
Explain the steps involved in bacteriophage DNA entering a bacterial cell.

last question.


um... is that exactly how the question was asked? or did you paraphrase it?

This post was edited by Cyba on Jan 16 2014 03:27pm
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