At first, no.
But after I change the settings, every few times I launch the game it begins to get buggy (transparent ground, black/unrendered models, etc), and then it crashes.
The only fix I know is going into Documents and deleting the Archeage folder there (it is the cache folder, not the entire game). This will allow you to have bug-free settings, and as far as I know, is just a temporarily solution.