The only boss fights I have lost to are the Eidolons I believe... Only reason why is because you have to scan them and work your party members to be able to combat them correctly. I lost the first few times because doom was running out or was confused on how to race their GE bar properly.
You should be continuously changing paradigms anyways, like Commando-Synergist-Sabetour to Commando-Ravager-Ravager to Commando-Sentinel/Ravager-Medic, etc. I don't think I have use many items in the game besides maybe 1-2 phoenix downs and a couple of potions at the start.
This post was edited by SniXSniPe on Mar 11 2010 06:39pm