They definitely made changes. Last season up to release of ROTW I was using a FOH Pally that would do Countess, Arcane, Trav, Meph, Chaos, Nik, and cows. This lasted for several months. While ROTW has only been out for a couple weeks, I did make a Warlock that is now my primary for doing the same runs. Near same MF % (300+). I stopped doing Any yesterday (until it is TZ again) and question why I am still bothering with Trav & Meph.
Trav is what I really notice as I have yet to see any unique drop in 2 weeks. Meph has about 1 unique drop every 20+ runs, before I could get something crappy like The Diggler at least every 5-10 runs. Diablo has dropped in quality as well.
Overall I am seeing and sensing significantly less drops for uniques, though I am getting on average the same amount of runes.
for items i need to do tons of runs,as for runes..i mostly see rals lol idk why XD highest i found yet after doing maybe 500 runs is a lem rune