Looking for advice
Good class combinations
Gear expectations etc

Highest lvl so far is 46
Just solo play messing around
Didn't play for a couple years coming back trying to see what direction I should go

A ton of good combos out there, I would start by googling Grim league , it's a mod that adds a good amount of content to the game , as for a good build/class combination grimtools has a lot of guides, still up to date.

Grim dawn is awesome. I have no advice but i know it has a lot of expansions and has been tempting me to give it another go. I have a character similar level to you i fooled around on. I need to look into grim league like guy above me mentioned

This site can give you some ideas
https://www.grimtools.com/

There is a new expansion coming to grim dawn soon.
So may see a spike in people talking about GD soon.