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Manchester United interim boss Ole Gunnar Solskjaer hopes forwards Romelu Lukaku and Alexis Sanchez can "step up" as the Red Devils could be without nine senior players against Crystal Palace.
Ander Herrera, Jesse Lingard and Juan Mata were injured during the first half of Sunday's match against Liverpool.
Marcus Rashford played most of the 0-0 draw with an ankle injury and is a doubt for Wednesday's fixture.
Teenagers Angel Gomes, Tahith Chong and Jimmy Garner will be involved.
Gomes, 18, is the only one of the academy trio to have made a Premier League appearance.
As well as Herrera, Lingard and Mata, United will be without defenders Phil Jones, Antonio Valencia and Matteo Darmian, midfielder Nemanja Matic and forward Anthony Martial at Selhurst Park.
Argentina centre-back Marcos Rojo, who has made just three appearances this season, will also be involved after returning from a long-term injury.
https://www.bbc.co.uk/sport/football/47368717Pretty much whole first team out