Downie out 7-10 days

nope

Then they're screwed

well he can be bought out but it wont be a compliance buyout

Dupuis to have acl surgery. Likely out for the year

Pascal Dupuis is out for rest of the season with ACL injury.

Seidenberg out the rest of the year with torn acl/mcl

Not technically an injury but Yak City is a healthy scratch again.

Ryan O’Reilly might miss Thursday’s game against Ottawa because of a bizarre shoulder injury he suffered in celebrating a goal Monday night.
O’Reilly hurt his left shoulder while celebrating the Avs’ third goal, by Paul Stastny. Essentially, he got it jammed while extending his left arm into the group hug. The Avs say he is day-to-day, so we’ll see tomorrow if he plays or not against Ottawa.

Galchenyuk out 6 weeks with a broken hand
Nabokov out 2 weeks with a lower body injury
Luongo will reportedly be out for a week or two with an ankle injury.
Eric Staal out a week with a lower body injury
Mikko Koivu out four to six weeks after ankle surgery
Derek Dorsett out four to six weeks with a broken leg