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Sep 3 2021 12:18pm
Quote (badasses @ 2 Sep 2021 14:22)
it does have antiviral properties, but proven in animals and not humans

i was curious so i looked up if there are actually any clinical studies with ivermectin because i recall some third world countries using it quite a bit when covid vaccines weren't readily available (think latin america and south africa)

here's what i found within 2 minutes of searching and i didn't cherry pick

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00239-X/fulltext#seccesectitle0024

https://www.sciencedirect.com/science/article/pii/S0166354220302011#:~:text=Ivermectin%20binds%20to%20and%20destabilises,normal,%20more%20efficient%20antiviral%20response.

https://www.nature.com/articles/s41429-020-0336-z

so it's not completely crazy, it's not FDA approved, but there are studies and countries using it since 2020 that suggests it could be explored


No, it is completely crazy.

Ivermectin is not plausible. It does not work. All studies in favour of IVM are junk papers and scientifically wrong. Many studies with proper scientific controls and proper peer evaluation have shown that Ivermectin does not work against covid 19 and if taken improperly can lead to over doses

Do not fall for the horse paste take, it's the worst narrative other than microchips being attached to this vaccine rollout
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Sep 3 2021 12:45pm
Quote (Subzer0isGG @ Sep 3 2021 11:04am)
Not a fox viewer at all, contrary to popular belief.

But you guys think CNN is any better?

Just curious...

Check out edmontons river valley. It's a gorgeous day and rivervalley is massive. Green space larger than Central park


It's more like, I'm inside a Canadian legislature shouldn't the TV be broadcasting something local lol 😆

Today's kinda a mulligan day so after lunch I might go down there. I did a day trip to Calgary yesterday to meet old friends and it's funny how similar both cities are lol
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Sep 3 2021 12:47pm
Quote (Hizkuntza @ Sep 3 2021 12:45pm)
It's more like, I'm inside a Canadian legislature shouldn't the TV be broadcasting something local lol 😆

Today's kinda a mulligan day so after lunch I might go down there. I did a day trip to Calgary yesterday to meet old friends and it's funny how similar both cities are lol


F U
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Sep 3 2021 12:49pm
Quote (Hizkuntza @ 3 Sep 2021 14:45)
It's more like, I'm inside a Canadian legislature shouldn't the TV be broadcasting something local lol 😆

Today's kinda a mulligan day so after lunch I might go down there. I did a day trip to Calgary yesterday to meet old friends and it's funny how similar both cities are lol


They each act better than the other but no matter which city you're in it's still Alberta :banana:
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Sep 3 2021 01:02pm
Quote (Meatstick @ 3 Sep 2021 12:49)
They each act better than the other but no matter which city you're in it's still Alberta :banana:


Gods country
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Sep 3 2021 01:06pm
Quote (Bruin @ Sep 3 2021 12:18pm)
No, it is completely crazy.

Ivermectin is not plausible. It does not work. All studies in favour of IVM are junk papers and scientifically wrong. Many studies with proper scientific controls and proper peer evaluation have shown that Ivermectin does not work against covid 19 and if taken improperly can lead to over doses

Do not fall for the horse paste take, it's the worst narrative other than microchips being attached to this vaccine rollout


Did you actually read the the articles and the journals that they're published in? The journal of antibiotics and antiviral research aren't properly peer reviewed?

Authors working at the Peter Doherty Institute for Infection and Immunity and the Biomedicine Discovery Institute in Australia are totally just making horse paste stuff up? These articles are published back in 2020, before Invermectin became popular and people were just looking to see if things work.

Again, I am not advocating that the general public go take an unproven and unapproved drug over taking the vaccine but ignoring everything on the other side pretty much puts you in the same camp as the microchip 5g guys, except on the opposite spectrum.

If you can produce some counter argument papers that say otherwise, I am very open to reading them. Even the WHO right now says it's inconclusive which is my stance. The big problem now is people are blindly taking the drug so it's hard for get good controlled clinical data for it to be confirmed, but it has not been disproven yet as you've claimed already.

Final note: there's different versions of the drugs, ones for human and ones for animals, both of which I wouldn't personally recommend anyone take right now, but taking the latter would be extra foolish.

This post was edited by badasses on Sep 3 2021 01:07pm
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Sep 3 2021 01:19pm
if you look at the countries it was being tested in its generally like 3rd world countries which imo is usually not a very good sign
i look at it like this it might work or help and if it does awesome for those countries without vaccine access

but there are better options why would you choose to take that based on limited studies in like peru when the vaccines have like 100x the studies and tests from 1st world countries with top doctors and scientists and technology
the vaccines arent safe but things 3rd world countries use out of desperation are safe and more efective! go smoke more crack anti vaxxers :rofl:

This post was edited by dragoneth on Sep 3 2021 01:25pm
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Sep 3 2021 01:33pm
Quote (Meatstick @ Sep 3 2021 12:49pm)
They each act better than the other but no matter which city you're in it's still Alberta :banana:



Pfft I’ve lived in Ottawa. It’s a sleepy concrete jungle of people who would live in Toronto if they could. Calgary >
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Sep 3 2021 01:44pm
Quote (StayPositive @ Sep 3 2021 03:33pm)
Pfft I’ve lived in Ottawa. It’s a sleepy concrete jungle of people who would live in Toronto if they could. Calgary >



lmfao
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Sep 3 2021 01:50pm
Hi, scientist here. Y'all made the mistake of talking science again.

Quote (badasses @ Sep 2 2021 04:22pm)
it does have antiviral properties, but proven in animals and not humans

i was curious so i looked up if there are actually any clinical studies with ivermectin because i recall some third world countries using it quite a bit when covid vaccines weren't readily available (think latin america and south africa)

here's what i found within 2 minutes of searching and i didn't cherry pick

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00239-X/fulltext#seccesectitle0024

https://www.sciencedirect.com/science/article/pii/S0166354220302011#:~:text=Ivermectin%20binds%20to%20and%20destabilises,normal,%20more%20efficient%20antiviral%20response.

https://www.nature.com/articles/s41429-020-0336-z

so it's not completely crazy, it's not FDA approved, but there are studies and countries using it since 2020 that suggests it could be explored


Study one has a tiny sample size (45) and used more than the recommended IVM dose per kg body weight (0.6 mg/kg vs 0.2 mg/kg), and still didnt find a difference in viral load reduction unless patients absorbed more of it, which suggests pharmacokinetics is a barrier to standardizing IVM treatment. If you bothered to read this at all, you'd notice the authors say these things:

Code
No differences in clinical evolution at day-7 and day-30 between groups were observed.
Large trials with clinical endpoints are necessary to determine the clinical utility of IVM in COVID-19.


Study 2 is the joke of a study that got Pierre Kory et al started on this nonsense. It's in vitro (cells in a petri dish). They used a cell type that isn't representative of human anything at all (Vero = monkey kidney cell line). Even if the cell type was representative of human anything, the Vero cells lack TMPRSS2 (a protein required for viral infection that makes it more efficient), meaning that this isn't representative of a true viral infectious process. Additionally, these cells are Vero-hSLAM, which expresses the receptor for the measles virus. Furthermore, these cells don't make/secrete interferons, which are host antiviral molecules that play roles in stopping viral infections and interact with the virus. Why would anyone take a study like this seriously when the cell type is wrong, lacks the proper host proteins for viral propagation, and expresses proteins that have no business in SARS-CoV-2 replication? It's a horseshit (pun intended) study. Guess what else would work in that study to stop viral replication? Shooting the infected cells in a petri dish with a fucking gun. Does that mean you're gonna shoot yourself to prevent COVID-19?

Study 3 isn't even an actual study, but rather a review that cites study 1 and a bunch of other in vitro (cells in a petri dish) studies, most of which aren't for SARS-CoV-2. None of this is in anything living. Using this as justification for IVM being an antiviral is equivalent to wishful thinking.

This is why you shouldn't interface with scientific publications if you don't have the training to dissect them or the willingness to take the extra time that you'd need to read and understand its contents to compensate.

Here is some actual science.

Recent preprint showing IVM (and a related drug in the same family, Moxidectin) can't even inhibit viral replication in vitro (cells in a petri dish) for HUMAN cells: https://www.biorxiv.org/content/10.1101/2021.05.17.444467v2
Largest, most recent completed RCT for IVM showing that IVM made people need a ventilator sooner rather than helping: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06348-5#Abs1
Review of 10 IVM studies showing that it doesn't do shit clinically: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab591/6310839

Quote (KrWWW @ Sep 2 2021 04:44pm)
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19

https://pubmed.ncbi.nlm.nih.gov/34466270/


These people literally fanboy over IVM and don't cite/show anything new. They are citing Kory's group of ambulance chasing MD dipshits (FLCCCA) who literally stand outside hospitals and try to override the autonomy of hospital physicians in caring for COVID patients by offering desperate family members IVM prescriptions. This was evidenced by this disgusting ruling from Ohio: https://www.cincinnati.com/story/news/2021/08/30/ivermectin-lawsuit-butler-county-judge-orders-hospital-treat-covid-19-patient-drug/5647432001/
In the above example, the hospitalized patient was prescribed a fucking massive dose of IVM by the doctor chud (30 mg daily, which, at my body weight of 185 pounds/84 kg, is nearly 2x the approved dose for parasitic infection). These people are betraying their MD training and safe drug dosing for IVM. It's fundamentally absurd and dangerous in the absence of scientific evidence.

Quote (dragoneth @ Sep 3 2021 03:19pm)
if you look at the countries it was being tested in its generally like 3rd world countries which imo is usually not a very good sign
i look at it like this it might work or help and if it does awesome for those countries without vaccine access

but there are better options why would you choose to take that based on limited studies in like peru when the vaccines have like 100x the studies and tests from 1st world countries with top doctors and scientists and technology
the vaccines arent safe but things 3rd world countries use out of desperation are safe and more efective! go smoke more crack anti vaxxers :rofl:


There is truth in this, as the body of "evidence" for IVM that Kory et al cite is comprised of cherrypicked, deceptively analyzed RCT data from low-middle income countries that lack infrastructure, training, and knowledge on how to properly design and execute a RCT.

Here you can read about how poorly studies like this were done (aka made up out of thin air) and subsequently withdrawn: https://www.buzzfeednews.com/article/stephaniemlee/ivermectin-covid-study-suspect-data and https://www.theguardian.com/science/2021/jul/16/huge-study-supporting-ivermectin-as-covid-treatment-withdrawn-over-ethical-concerns

Turn off the knuckledragging gorilla fuck that is Joe Rogan and stop fawning over horse paste as a culture war icon.
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