Quote (Cyba @ Jan 18 2014 05:18pm)
ok now you're just picking out certain words that I say instead of seeing how I use those words and if they correlate to anything that you're trying to say. Never lose sight of your initial argument
here's what you originally posted:
ok, so we're going to skip to the part where you meant to say "then" instead of "than" because we both know what you meant.
Here's the gist of what you originally put: B cells present antigen to T cells. T cells then activates several over B cells (meaning you said subsequently, immediately after activation, it activates other B cells).
That's where you're wrong in the first place. The potential activation of other B cells by that one T cell does not happen that fast. That T cell is bound to that B cell (in the T cell area) and moves to the primary and secondary follicles of the lymph node after the cognate interaction (out of contact with the rest of the B cells). Do you know how long the B cell and T cells are attached for? 3-4 weeks.... hence why you don't immediately generate non-IgM antibodies so early in an infection and hence why it takes so long to clear an infection. The division process takes a lot of time and energy (which gives you your symptomatic feeling of fatigue during an infection). That T cell is not going to be activating any other B cells for a very, very long time, probably not until the infection is over. Its progenies can still activate other B cells, but not that single T cell that was bound to that initial B cell.
omg if u read a little further I did say "which further binds to this specific antigens"
I already knew T cells can't be activating other B cells with different variable region than the one that was presented
So that's why I assumed u would think I wouldn't think that T cells activate bcells for different antigens
So what use been saying is that T cells are basically like a cascade where like there's only a single orgin
That 1 T cell needs time to replicate and divide which (the progeny ,not parent cells) activates more B cells for that specific antigen?
So overall a B cell present antigen to T cell , T cell releases cytokines (I think u said something about cytokines not being right, I'll read that part later) , that T cell activates 1 B cell, and the T cell goes through mitosis/cytokinesis which produces "offspring" and those "offspring" are the ones to activate another single B cell
that have the same variable region and keeps going down the generation?
If I'm right on this, ur explaination of the infection and it's timing helped