Tldr version
Just updated the bios
It will Not let me select my NVME as a boot option
It defaults to some sata drive that does not have OS

the bios detects the drive in system information

Won't let me select it to boot

I've had this problem before and my only fix was to unplug everything but the OS drive then it detected it

Is the proper boot protocol selected?

You booting in UEFI or legacy csm mode? Legacy BIOS doesn't support nvme

Tried it both ways. Neither option let me select the drive
I wonder if the MSI boot loader doesn't like 5 drives. I unplugged one and then it magically detected all the other 4 as potential boot options. It's not like I'm using all the sata lanes.