Not sure a best answer for this, but i generally go in this order
1) Main story Line
2) Expansion story Line
3) Class Quests
4) Explore map and do Renown(Most will carry over into each season)
5) Level up glyphs, each to 16 then each to 46(Main 6 you will be using)--Grim Favor Tree of Whispers is good for materials/glyphs
6) Start farming master working materials, each to 4, then each to 8
7) Level up glyphs to 100
8) Farm up Pit to highest level you can farm in 60-100 seconds
Great info! I downloaded Vessel and started playing that and I think it completely skipped the main story line lol.